CRY1 Inhibitors
CRY1 inhibitors constitute a diverse array of chemicals designed to directly or indirectly modulate the function of Cryptochrome 1 (CRY1), a crucial component of the circadian clock. Within this class, KL001 and KL044 serve as direct inhibitors, targeting the PER-ARNT-SIM (PAS) domain of CRY1. By disrupting the interaction between CRY1 and CLOCK-BMAL1, these compounds inhibit circadian transcription, providing precise tools for investigating the molecular intricacies of circadian rhythm control. On the other hand, Selisistat (EX-527) takes an indirect approach by influencing CRY1 through SIRT1 inhibition. By altering CRY1 acetylation, Selisistat affects circadian regulation, showcasing the interconnectedness between CRY1 and SIRT1 in the circadian clock machinery. Nobiletin and Resveratrol also exert their effects indirectly, impacting CRY1 through the activation of the Nrf2-ARE and AMPK pathways, respectively. Nicotinamide (NAM) represents another indirect modulator of CRY1 by inhibiting SIRT1. The inhibition of SIRT1, in turn, affects CRY1 acetylation, adding another layer of complexity to the regulation of circadian rhythms. Vorinostat (SAHA) indirectly influences CRY1 by inhibiting histone deacetylases (HDACs), potentially altering CRY1-associated histone acetylation.
JIB-04 offers an indirect modulation of CRY1 through the inhibition of Jumonji histone demethylases, suggesting an epigenetic regulatory mechanism in CRY1-dependent circadian control. Parthenolide takes a different route, indirectly influencing CRY1 by inhibiting the NF-κB pathway, leading to CRY1 degradation and subsequent changes in circadian gene expression. Apigenin, through the inhibition of the Akt/mTOR pathway, indirectly modulates CRY1 by impacting its phosphorylation and stability. This showcases the intricate crosstalk between signaling pathways and the regulation of CRY1 in circadian rhythm control. CGP 60474, by inhibiting casein kinase 2 (CK2), indirectly influences CRY1, altering its phosphorylation patterns and stability. Melatonin, acting through the activation of the MT1 receptor, indirectly modulates CRY1, resulting in altered CRY1 levels and circadian regulation. This compound adds another layer of complexity to the regulatory network governing circadian processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KL001 | 309928-48-1 | sc-488559 sc-488559A sc-488559B | 5 mg 10 mg 25 mg | $72.00 $198.00 $292.00 | ||
KL001 is a small molecule that inhibits the activity of CRY1 by binding to its PER-ARNT-SIM (PAS) domain. This interaction interferes with CRY1's ability to repress CLOCK-BMAL1-mediated transcriptional activation, disrupting the circadian clock machinery and providing a direct means to inhibit CRY1 function in the regulation of circadian rhythms. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $87.00 | 32 | |
Selisistat inhibits SIRT1, a deacetylase known to interact with and deacetylate CRY1. By blocking SIRT1 activity, Selisistat indirectly modulates CRY1 function. This disruption of the SIRT1-CRY1 interaction alters the acetylation status of CRY1, impacting its regulatory role in the circadian clock and providing an indirect means to inhibit CRY1. | ||||||
Nobiletin | 478-01-3 | sc-202733 | 10 mg | $189.00 | 2 | |
Nobiletin influences CRY1 indirectly by activating the Nrf2-ARE pathway. By promoting Nrf2 nuclear translocation, Nobiletin upregulates the expression of antioxidant genes, leading to the degradation of CRY1. This indirect modulation suggests Nobiletin as a potential compound for influencing CRY1 levels through the Nrf2-ARE pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol indirectly influences CRY1 by activating the AMPK pathway. Through AMPK activation, Resveratrol promotes the degradation of CRY1, modulating its levels and, consequently, impacting circadian rhythm regulation. This indirect mechanism positions Resveratrol as a compound capable of influencing CRY1 through the AMPK signaling cascade. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide (NAM) indirectly modulates CRY1 through its inhibitory effect on SIRT1, a deacetylase known to interact with CRY1. By inhibiting SIRT1, NAM disrupts the deacetylation process, altering the acetylation status of CRY1 and influencing its regulatory role in the circadian clock. This indirect modulation highlights NAM as a potential regulator of CRY1 function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, also known as SAHA, inhibits histone deacetylases (HDACs), including those that may interact with CRY1. By blocking HDAC activity, Vorinostat indirectly modulates CRY1 function through alterations in histone acetylation patterns, affecting circadian gene expression. This indirect impact suggests Vorinostat as a compound influencing CRY1 via HDAC inhibition. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
JIB-04 indirectly influences CRY1 by inhibiting Jumonji histone demethylases. By blocking demethylase activity, JIB-04 alters the methylation status of histones associated with circadian genes, impacting their transcriptional regulation. This indirect modulation suggests JIB-04 as a compound capable of influencing CRY1-dependent circadian processes through epigenetic mechanisms. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide indirectly modulates CRY1 through its inhibitory effect on the NF-κB pathway. By inhibiting NF-κB activation, Parthenolide upregulates the expression of circadian clock genes, leading to the degradation of CRY1. This indirect modulation positions Parthenolide as a potential compound for influencing CRY1 levels through the NF-κB signaling cascade. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin indirectly influences CRY1 by inhibiting the Akt/mTOR pathway. By blocking Akt/mTOR signaling, Apigenin alters the phosphorylation status of CRY1, impacting its stability and function in circadian rhythm regulation. This indirect modulation suggests Apigenin as a compound capable of influencing CRY1-dependent circadian processes through the Akt/mTOR signaling cascade. | ||||||
CGP-60474 | 164658-13-3 | sc-507525 | 5 mg | $165.00 | ||
CGP 60474 inhibits casein kinase 2 (CK2), an enzyme that phosphorylates CRY1. By blocking CK2 activity, CGP 60474 indirectly modulates CRY1 function through alterations in CRY1 phosphorylation patterns, affecting its stability and regulatory role in the circadian clock. This indirect modulation positions CGP 60474 as a potential compound for influencing CRY1 through CK2 inhibition. | ||||||