CRABP-I Activators
CRABP-I (Cellular Retinoic Acid-Binding Protein I) activators belong to a specific chemical class that interacts with and modulates the activity of CRABP-I proteins within biological systems. CRABP-I is a key member of the cellular retinoic acid-binding protein family, primarily involved in the intracellular transport and modulation of retinoic acid, a metabolite of vitamin A. CRABP-I activators are characterized by their ability to bind to CRABP-I, which subsequently triggers a conformational change in the protein's structure. This conformational alteration is believed to impact the binding affinity of CRABP-I for retinoic acid molecules.
By influencing the conformation of CRABP-I, activators may indirectly impact the cellular retinoic acid signaling pathway. The intricate interplay between CRABP-I, its ligands, and the activators is thought to have implications for cellular differentiation, proliferation, and other vital physiological processes. The precise mechanisms by which CRABP-I activators modulate the protein's function are still a subject of ongoing research, as scientists strive to unravel the complex molecular interactions that underlie this class of compounds.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Naturally, retinoic acid itself can induce the expression of CRABP-I. It acts as a ligand for nuclear retinoic acid receptors (RARs), leading to changes in gene transcription, including the upregulation of CRABP-I. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Retinol is the precursor of retinoic acid. It can be converted to retinoic acid and subsequently induce CRABP-I expression through the activation of RARs. | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
Tazarotene is a synthetic retinoid commonly studied in the research of skin conditions like psoriasis and acne. It activates RARs, leading to the upregulation of CRABP-I. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
Another synthetic retinoid used to treat severe acne. It affects cell differentiation and growth by modulating gene expression, which may include CRABP-I. | ||||||
Adapalene | 106685-40-9 | sc-203803 sc-203803A | 10 mg 50 mg | $66.00 $332.00 | 2 | |
This is a retinoid agent in research known to affect gene expression through RARs and might influence CRABP-I levels. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
Bexarotene is a retinoid that activates RARs and may lead to the induction of CRABP-I. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
Prescribed for severe chronic hand eczema, alitretinoin is a retinoid that modulates gene expression through RARs, potentially impacting CRABP-I expression. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $151.00 | 1 | |
Used to treat psoriasis and other skin conditions, acitretin is a synthetic retinoid that can affect gene expression pathways including those involving CRABP-I. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Also known as N-(4-hydroxyphenyl)retinamide (4-HPR), fenretinide is a synthetic retinoid that has shown potential in cancer research. It might influence CRABP-I expression as part of its mechanism of action. | ||||||
AM 80 | 94497-51-5 | sc-203816 sc-203816A | 10 mg 50 mg | $155.00 $620.00 | 1 | |
This synthetic retinoid is studied in the research of acute promyelocytic leukemia. It binds to RARs and can affect gene expression, including the induction of CRABP-I. | ||||||