Coronin 2B Inhibitors

Chemicals classified as Coronin 2B Inhibitors are not direct inhibitors but rather target processes and signaling pathways that Coronin 2B is known to influence. These compounds predominantly affect the cytoskeletal framework of the cell, particularly actin filaments and microtubules, which are critical for maintaining cell shape, enabling cellular movement, and facilitating intracellular transport. By modulating actin dynamics, these inhibitors can indirectly affect the role of Coronin 2B in organizing the actin cytoskeleton, influencing cell motility, and possibly affecting other cellular functions where Coronin 2B is involved.

The chemical inhibitors listed can have a profound impact on cellular actin dynamics. Latrunculin B and Cytochalasin D can cause depolymerization of actin filaments, leading to the disassembly of actin structures with which Coronin 2B interacts. Compounds like CK-666, Swinholide A, and SMIFH2 target actin nucleation and elongation, processes fundamental to the formation and maintenance of the actin cytoskeleton and modulating Coronin 2B's activity. ML141 and NSC 23766 can alter the activity of small GTPases such as Cdc42 and Rac1, which are crucial for actin filament branching and stabilization, processes that could be modulated by Coronin 2B.