COL9A1 Inhibitors
COL9A1 inhibitors belong to a distinctive chemical class renowned for their capacity to modulate the activity of collagen type IX alpha 1 (COL9A1). Collagens constitute a family of fibrous proteins integral to the structural integrity of various tissues, including cartilage and intervertebral discs. Specifically, COL9A1 is a member of the collagen type IX family, contributing to the formation of heterotrimeric molecules essential for maintaining the structural and functional integrity of the extracellular matrix in cartilage. The inhibitory action of compounds within this class primarily focuses on disrupting the normal function of COL9A1, thereby influencing the assembly and stability of collagen fibrils. Through intricate interactions with other collagen types, COL9A1 plays a critical role in the maintenance of tissue architecture and biomechanical properties.
COL9A1 inhibitors underscores the significance of targeting specific molecular pathways associated with collagen formation, particularly in the context of conditions where collagen dysregulation is implicated. By selectively inhibiting COL9A1, these compounds aim to elucidate the nuanced intricacies of collagen assembly and contribute to a deeper understanding of the underlying molecular mechanisms governing tissue homeostasis. Researchers explore the abilities of COL9A1 inhibitors not only as tools for dissecting collagen biology but also for shedding light on pathogenic processes involving collagen abnormalities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
A lathyrogen that inhibits lysyl oxidase, an enzyme responsible for the cross-linking of collagen fibers, potentially affecting the integrity of collagen matrices including COL9A1. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Binds to pyridinoline, which is a cross-linking compound in collagen fibers, potentially disrupting the maturation and stability of the extracellular matrix where COL9A1 is located. | ||||||
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $199.00 $632.00 | 8 | |
A metalloprotease inhibitor that can inhibit enzymes involved in the degradation of extracellular matrix components, potentially affecting the turnover of collagen including COL9A1. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
A broad-spectrum matrix metalloproteinase (MMP) inhibitor that can prevent the degradation of collagens, potentially influencing the integrity of collagen networks involving COL9A1. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Another MMP inhibitor that can protect collagens from degradation, potentially maintaining the structural integrity of collagen assemblies where COL9A1 is a component. | ||||||
D-(−)-Threose | 95-43-2 | sc-214795 | 50 mg | $73.00 | ||
A reducing sugar that can react with amino groups in collagen, leading to the formation of advanced glycation end products (AGEs) that can disrupt collagen fiber structure and function. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
An inhibitor of collagen synthesis, which can lead to a reduction in the overall production and deposition of collagens, including potentially COL9A1. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
Known to inhibit collagen synthesis, which could result in decreased levels of extracellular matrix components like COL9A1. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Inhibits collagen synthesis and may affect the deposition and quality of extracellular matrix containing COL9A1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Inhibits lysyl oxidase-like enzymes, potentially affecting the cross-linking and stabilization of collagen matrices that include COL9A1. | ||||||