COL5A3 Activators
Collagen, the most abundant protein in the human body, has a pivotal role in the structural integrity of various tissues. The different types of collagens are constructed from different combinations of alpha chains, among which is the COL5A3, a significant component of type V collagen. Type V collagen's presence in tissues containing type I collagen is believed to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. The unique composition and function of type V collagen underscores the importance of maintaining optimal levels of its alpha chains, including COL5A3. The chemicals listed above are not direct activators of COL5A3, but they play a significant role in influencing the pathways that can lead to the enhanced synthesis, stabilization, and functionality of the COL5A3 chains within the type V collagen structure.
Starting with basic molecules like Ascorbic Acid, L-Proline, and L-Lysine, these compounds support the foundational steps of collagen synthesis. Ascorbic acid, for instance, enhances hydroxylation of proline residues in collagen, a crucial step in collagen chain formation. In contrast, L-Proline and L-Lysine directly contribute to the structure and cross-linking of collagen fibers. Furthermore, BMP-2, A-83-01, and compounds like Zinc Sulfate and Manganese(II) sulfate provide another dimension to the regulation of COL5A3 synthesis and type V collagen formation. They operate by modulating specific pathways, like the SMAD signaling or the TGF-β signaling, which have a bearing on collagen synthesis. The intricate interplay between these pathways and collagen synthesis means that any modulation can lead to changes in the synthesis of COL5A3 and its subsequent assembly into type V collagen fibers. Chitosan, for example, enhances the collagen synthesis during wound healing, indirectly affecting COL5A3's role in type V collagen.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid promotes hydroxylation of proline residues in collagen, enhancing collagen synthesis. By doing so, it supports COL5A3 chain synthesis, stabilizing the formation of heterotypic fibers containing type V collagen. | ||||||
L-Proline | 147-85-3 | sc-397196 sc-397196A sc-397196B sc-397196C | 25 g 100 g 1 kg 5 kg | $38.00 $133.00 $208.00 $978.00 | ||
L-Proline is an amino acid crucial for collagen synthesis. It serves as a precursor for proline residues in the COL5A3 chain, thus facilitating proper chain formation and stability of type V collagen structures. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $95.00 $263.00 $529.00 | ||
L-Lysine is involved in collagen cross-linking. The cross-linking process stabilizes the COL5A3 chains in type V collagen, maintaining its structural integrity in tissues. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper is essential for the function of lysyl oxidase, an enzyme vital for collagen cross-linking. Proper cross-linking ensures the stability and structural integrity of COL5A3 chains within type V collagen fibers. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
A-83-01 is an inhibitor of TGF-β type I receptor ALK5 kinase, ALK4, and ALK7. By modulating TGF-β signaling, it indirectly promotes collagen synthesis pathways, potentially leading to enhanced COL5A3 chain synthesis. | ||||||
Chitosan | 9012-76-4 | sc-221421 sc-221421A sc-221421B sc-221421D sc-221421C | 10 g 25 g 100 g 8 kg 500 g | $41.00 $55.00 $135.00 $3339.00 $298.00 | 6 | |
Chitosan promotes wound healing and collagen synthesis. It can enhance the formation and stabilization of COL5A3 chains by upregulating processes that support type V collagen assembly in response to tissue repair stimuli. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Elevated homocysteine levels can modulate collagen synthesis. By influencing collagen-related pathways, homocysteine can indirectly affect the synthesis and stabilization of COL5A3 chains in type V collagen structures. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is crucial for collagen synthesis and wound healing. Zinc's role in collagen formation processes can influence the synthesis and stabilization of COL5A3 chains, promoting the integrity of type V collagen fibers. | ||||||
Manganese(II) sulfate monohydrate | 10034-96-5 | sc-203130 sc-203130A | 100 g 500 g | $41.00 $107.00 | ||
Manganese is essential for the function of prolidase, an enzyme involved in collagen synthesis. Its presence ensures the proper formation of COL5A3 chains, which are vital for the structural role of type V collagen in tissues. | ||||||