COL29A1 Inhibitors
COL29A1 inhibitors are a diverse group of chemical compounds that indirectly reduce the functional activity of COL29A1, a protein involved in the assembly and stabilization of collagen fibers. Halofuginone, by targeting the synthesis of collagen type I, indirectly impairs the functionality of COL29A1, as it plays a crucial role in collagen fiber formation. Similarly, Tranilast and Suramin, by inhibiting cytokine release and growth factor signaling respectively, decrease fibroblast activity and thus the synthesis of extracellular matrix proteins, including COL29A1. Monensin's alteration of intracellular ion concentrations can affect the glycosylation and stability of proteins like COL29A1, while Diphenylpyraline's H1 receptor antagonism may reduce the inflammatory response and consequently the demand for tissue repair proteins such as COL29A1.
Additionally, the heavy metal compound Cadmium Chloride induces oxidative stress, which modifies the synthesis of matrix components, potentially decreasing the levels of COL29A1. Similar inhibitory effects on COL29A1 are seen with Mitomycin C and Cycloheximide, which reduce fibroblast proliferation and general protein synthesis, respectively. Clioquinol, by chelating metal ions necessary for enzyme functions, interferes with the assembly of collagen fibers, affecting COL29A1's role in this process. Furthermore, Disulfiram's inhibition of aldehyde dehydrogenase and Phenanthroline's metal ion chelation both disrupt the collagen fiber crosslinking and synthesis processes, thereby influencing the stability of collagen networks and diminishing COL29A1 function. Genistein, as a tyrosine kinase inhibitor, further contributes to the reduction of COL29A1-mediated extracellular matrix protein synthesis by attenuating fibroblast proliferation. Collectively, these compounds, through their specific actions on various biochemical and cellular pathways, lead to a concerted decrease in the functional activity of COL29A1, illustrating a range of indirect strategies to inhibit this protein's role in extracellular matrix integrity and stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
Halofuginone is an inhibitor of collagen type I synthesis. By inhibiting the synthesis of collagen type I, it indirectly diminishes the functional activity of COL29A1, which is involved in the assembly and stabilization of collagen fibers. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that alters intracellular sodium and hydrogen concentrations. By disrupting ion gradients, it can lead to altered glycosylation of proteins, potentially affecting the stability and function of extracellular matrix proteins such as COL29A1. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin is a multifunctional molecule that inhibits various growth factors. By inhibiting growth factor signaling, it can lead to reduced fibroblast activity, and thus less synthesis of extracellular matrix components, including COL29A1. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Tranilast inhibits the release of cytokines from mast cells. This can lead to a decrease in fibrosis and the synthesis of matrix proteins, including COL29A1, as part of the fibrotic process. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium Chloride is a heavy metal compound that can induce oxidative stress. Oxidative stress can lead to a modification of extracellular matrix component synthesis, including a decrease in proteins like COL29A1. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C is a DNA crosslinker that can reduce fibroblast proliferation. Reduced fibroblast activity leads to a decrease in the synthesis of extracellular matrix proteins, including COL29A1. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis. By inhibiting general protein synthesis, it can lead to a reduced production of extracellular matrix proteins like COL29A1. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
Clioquinol chelates metal ions, which are necessary cofactors for many enzymes. By chelating these ions, it can interfere with the synthesis and assembly of collagen fibers, thus affecting the stability and function of COL29A1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram inhibits aldehyde dehydrogenase, which can lead to altered crosslinking of collagen fibers. This can influence the stability of collagen networks where COL29A1 is involved. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
Phenanthroline chelates metal ions such as iron and copper, which are essential for the hydroxylation of proline and lysine residues in collagen synthesis. By inhibiting this process, it can lead to impaired COL29A1 function. | ||||||