Molecular structure of Clioquinol, CAS Number: 130-26-7
Clioquinol (CAS 130-26-7)
See product citations (2)
Alternate Names:
5-Chloro-7-iodo-8-quinolinol
Application:
Clioquinol is a metal chelating ligand that inhibits certain enzymes related to DNA replication
CAS Number:
130-26-7
Purity:
≥96%
Molecular Weight:
305.50
Molecular Formula:
C9H5ClINO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clioquinol is extensively used in microbiological research, especially for studying its antimicrobial properties. It is particularly effective against fungi and certain bacteria, making it a useful agent for investigating mechanisms of microbial inhibition and death. Research involving Clioquinol focuses on its ability to chelate essential metal ions, which is for understanding the disruption of metal-dependent enzymatic processes in microbes. Additionally, Clioquinol is employed in studies examining its effect on biofilm formation and its potential role in disrupting these complex microbial communities. Furthermore, its impact on cellular metal homeostasis provides a model for studying the broader implications of metal ion chelation in biological systems, including oxidative stress and metal-related toxicity.
Clioquinol (CAS 130-26-7) References
- Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. | Nguyen, T., et al. 2005. Proc Natl Acad Sci U S A. 102: 11840-5. PMID: 16087879
- Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. | White, AR., et al. 2006. J Biol Chem. 281: 17670-80. PMID: 16648635
- Clioquinol and vitamin B12 (cobalamin) synergistically rescue the lead-induced impairments of synaptic plasticity in hippocampal dentate gyrus area of the anesthetized rats in vivo. | Chen, WH., et al. 2007. Neuroscience. 147: 853-64. PMID: 17555879
- Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands. | Caragounis, A., et al. 2007. Biochem J. 407: 435-50. PMID: 17680773
- Hydroxyquinolines inhibit ribonucleic acid-dependent deoxyribonucleic acid polymerase and inactivate Rous sarcoma virus and herpes simplex virus. | Rohde, W., et al. 1976. Antimicrob Agents Chemother. 10: 234-40. PMID: 185949
- Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. | Adlard, PA., et al. 2008. Neuron. 59: 43-55. PMID: 18614028
- Clioquinol targets zinc to lysosomes in human cancer cells. | Yu, H., et al. 2009. Biochem J. 417: 133-9. PMID: 18764784
- Clioquinol-induced increase and decrease in the intracellular Zn2+ level in rat thymocytes. | Oyama, TM., et al. 2012. Life Sci. 91: 1216-20. PMID: 23044228
- [Clioquinol use for Dientamoeba fragilis infections is questionable]. | van Hunsel, F., et al. 2017. Ned Tijdschr Geneeskd. 161: D1477. PMID: 28880141
- Clioquinol, an alternative antimicrobial agent against common pathogenic microbe. | You, Z., et al. 2018. J Mycol Med. 28: 492-501. PMID: 29650464
- Clioquinol is a promising preventive morphological switching compound in the treatment of Candida infections linked to the use of intrauterine devices. | Pippi, B., et al. 2018. J Med Microbiol. 67: 1655-1663. PMID: 30256190
- Oral clioquinol is effective in the treatment of a fly model of Candida systemic infection. | Pippi, B., et al. 2019. Mycoses. 62: 475-481. PMID: 30600560
- Clioquinol inhibits cell growth in a SERCA2-dependent manner. | Lv, X., et al. 2021. J Biochem Mol Toxicol. 35: e22727. PMID: 33511738
- The Zinc Ionophore Clioquinol Reduces Parkinson's Disease Patient-Derived Brain Extracts-Induced Neurodegeneration. | Teil, M., et al. 2022. Mol Neurobiol. 59: 6245-6259. PMID: 35915387
- Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells. | Lv, X., et al. 2023. Chem Biol Interact. 369: 110268. PMID: 36396104
Inhibitor of:
α-defensin 6, 2810408P10Rik, 4930432O21Rik, 5730403M16Rik, A630033E08Rik, ADO, Arylsulfatase B, Ataxin-3, ATP13A2, AU017455, BDP1, C8orf70, Calgranulin B, Clusterin-L1, COL29A1, COMMD3, CPZ, Cytokeratin 14, Derlin-3, dsg1β, E330034G19Rik, ECHDC1, EG637776, Gl Syn, GSTM5, HAH1, HRCT1, ISCA1, Keratin 85, Lipocalin-10, Ly6G6c, Mel13, melanotransferrin, Metallothionein, Metallothionein 3, MOXD2, MTF-1, NAT-16, NFS1, PIH1D2, PP2A-Aβ, PRX2, PTPN13LY, S100A7A, SBP-2, SEP15, SLC39A11, STEAP, STEAP, TBG, TMC8, ZCCHC12, ZFP1, Zfp663, Zfp799, Zfp871, ZIP1, ZIP10, ZIP14, ZIP2, ZIP4, ZIP5, ZMAT1, ZNF142, ZNF191, ZNF202, ZNF256, ZNF336, ZNF407, ZNF552, ZNF555, ZNF589, ZNF598, ZNF618, ZNF654, ZNF682, ZNF688, ZNF701, ZNF708, ZNF77, ZNF800, ZnT-1, and ZnT-7.Activator of:
2610305D13Rik, ATP7A, BChE, COMMD10, COPT2, COX17, COX19, CTR1, Cup1, CUTC, EG236749, Ferroportin-1, Gigaxonin, MBLAC2, S-100A13, SCO1, SLC39A12, SLC39A13, TASK-2, Zfp738, ZIM1, ZNF214, ZNF74, ZnT-3, and ZnT-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clioquinol, 1 g | sc-201066 | 1 g | $45.00 | |||
Clioquinol, 5 g | sc-201066A | 5 g | $115.00 |