COL13A1 Inhibitors
COL13A1 inhibitors are a class of molecules designed to target and inhibit the activity of the COL13A1 gene or protein. COL13A1, also known as Collagen Alpha-1(XIII) Chain, is a member of the collagen family, a group of structural proteins that provide strength and stability to various tissues in the body, including skin, tendons, and blood vessels. COL13A1 specifically plays a crucial role in collagen fibrillogenesis, which is the process by which collagen fibers are formed and organized within the extracellular matrix. By inhibiting COL13A1, these inhibitors have the potential to impact collagen formation and affect the structural integrity of tissues.
COL13A1 inhibitors is driven by the understanding that alterations in collagen production and organization can have significant implications in various physiological and pathological processes. By targeting COL13A1, these inhibitors aim to modulate collagen deposition and organization, potentially influencing tissue biomechanics and function. This class of inhibitors holds promise in various research areas, including tissue engineering and regenerative medicine, as they could be used to manipulate collagen deposition to enhance tissue repair and regeneration.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
Halofuginone inhibits the synthesis of type I collagen, which may affect COL13A1 indirectly as they are both involved in the extracellular matrix and cell adhesion processes. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Tranilast suppresses the release of transforming growth factor-beta (TGF-β), which can regulate the synthesis of various collagens including potentially COL13A1. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
Pirfenidone decreases the production of TGF-β and downregulates collagen gene expression, which may indirectly affect COL13A1 levels. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Manumycin A inhibits Ras farnesyltransferase, which can indirectly influence the expression of various collagens by affecting cell signaling pathways that regulate ECM composition, potentially influencing COL13A1 expression. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 is an inhibitor of the TGF-β receptor, which modulates collagen synthesis, and thus could have an impact on COL13A1 expression indirectly. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2109761 is another TGF-β receptor kinase inhibitor which likely affects collagen gene expression, including that of COL13A1. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan blocks the action of angiotensin II which has been shown to reduce TGF-β expression and may indirectly reduce collagen accumulation, thereby potentially affecting COL13A1. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
D-Penicillamine can react with aldehydes released from lysine residues during collagen maturation, potentially altering collagen fibers and indirectly affecting the function of COL13A1. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine has been shown to influence the expression of various genes, including some related to collagen synthesis, and thus may have an indirect effect on COL13A1 expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate can inhibit the proliferation of fibroblasts and may decrease collagen production, which could indirectly impact the levels of COL13A1. | ||||||