Manumycin A CAS: 52665-74-4
MF: C31H38N2O7
MW: 550.7
An antibiotic that acts as a selective and vigorous inhibitor of Ras farnesyltransferase.

Manumycin A (CAS 52665-74-4)

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アプリケーション: An antibiotic that acts as a selective and vigorous inhibitor of Ras farnesyltransferase
CAS 番号: 52665-74-4
Purity: ≥96%
Molecular Weight: 550.7
Molecular Formula: C31H38N2O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Manumycin A is an antibiotic originally generated by Streptomyces parvulus that acts as a selective and vigorous inhibitor of Ras farnesyltransferase. The compound has been observed to block the activity of IKKβ by robustly and rapidly inhibiting TNF alpha induced phosphorylation of IκBα and NF-κB nuclear translocation. Studies indicate that Manumycin A has the ability to induce the dimerization of IKKβ and dissociation of IKK from IKKγ/NEMO, the adapter protein. Atherosclerosis studies report that Manumycin A decreases oxidative stress. Additionally, Manumycin A irreversibly inhibits neutral sphingomyelina, and has been shown to produce nitric oxide and induce apoptosis in leukemia cell studies. Manumycin A is an inhibitor of Farnesyl Transferase and N-SMase.


参考文献

1. Hara, M., et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 2281-2285. PMID: 8460134
2. Zou, Y., et al. 1996. J. Biol. Chem. 271: 33592-33597. PMID: 8969227
3. Arenz, C., et al. 2001. Chembiochem. 2: 141-143. PMID: 11828438
4. She, M., et al. 2005. Leukemia. 19: 595-602. PMID: 15744347
5. Bernier, M., et al. 2006. J. Biol. Chem. 281: 2551-2561. PMID: 16319058
6. Sugita, M., et al. 2007. Arterioscler. Thromb. Vasc. Biol. 27: 1390-1395. PMID: 17363690

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/ml), DMSO (10 mg/ml), DMF (20 mg/ml), 1:1 DMF:PBS (pH 7.2) (0.5 mg/ml), CHCl3, and MeOH. Insoluble in water.
保存方法 :
Store at -20° C
Boiling Point :
~863.6° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.60
IC50 :
GGTase I: IC50 = 180 µM; FTase: IC50 = 5 µM
Ki Data :
FPP: Ki= 1.2 µM
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
6438330
MDL Number :
MFCD00920782
SMILES :
CCCC[[email protected]@H](C)/C=C(\\C)/C=C(\\C)/C(=O)NC1=C[[email protected]]([[email protected]]2[[email protected]@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O

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Manumycin A  参考文献

See how others have used Manumycin A. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 11044431  Marra, DE. et al. 2000. Circulation. 102: 2124-2130.

PMID: # 8460134  Hara, M. et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 2281-2285.

PMID: # 28036370  PLoS Pathog. 12: e1006139.

Citations 1 to 3 of 3 total
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