COG5 Activators
COG5 Activators are a collection of chemical compounds that facilitate the enhancement of COG5 function by influencing various signaling pathways and cellular processes. Forskolin, through its activation of adenylate cyclase, increases intracellular cAMP levels, leading to the activation of cAMP-dependent pathways that enhance the role of COG5 in vesicular trafficking. Similarly, 8-Bromo-cAMP, a cell-permeable cAMP analog, activates PKA, which may amplify COG5's function by modulating similar cAMP-dependent pathways. Epigallocatechin gallate, by inhibiting multiple kinases, may indirectly augment COG5 activity by reducing the phosphorylation of proteins that negatively regulate COG5's role in vesicular transport. On the other hand, Phorbol 12-myristate 13-acetate, a potent PKC activator, could potentiate COG5's function through the phosphorylation of proteins within the COG5-associated vesicle trafficking pathway.
Furthermore, compounds that influence intracellular calcium levels, such as A23187 (a calcium ionophore), Ionomycin, and Thapsigargin, indirectly support COG5 activity by activating calcium-dependent signaling mechanisms. These increases in intracellular calcium can trigger a cascade of events that intersect with COG5's role in vesicular trafficking. Fusicoccin, by stabilizing the interaction between H+-ATPases and 14-3-3-3 proteins, may affect vesicular transport mechanisms that involve COG5. Sphingosine-1-phosphate enhances sphingosine kinase activity, potentially modulating sphingolipid signaling pathways that intersect with COG5's function in vesicle trafficking. Additionally, the PI3K inhibitor LY294002 may indirectly enhance COG5 activity by altering the PI3K/Akt pathway, affecting downstream vesicle trafficking processes. U73122, by inhibiting phospholipase C, and Okadaic Acid, by inhibiting protein phosphatases, both have the potential to modulate phosphorylation patterns within the cell, leading to the enhancement of COG5's role in the complex processes of vesicular trafficking. Together, these compounds leverage their influence on various biochemical pathways to enhance the functional activity of COG5 in a concerted manner.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can enhance COG5 function by stimulating cAMP-dependent pathways that COG5 is part of. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits multiple kinases, which could lead to a reduction in phosphorylation events that negatively regulate COG5, thus indirectly enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which may enhance COG5 activity through phosphorylation of proteins in the COG5-associated vesicle trafficking pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 increases intracellular calcium levels, potentially enhancing COG5 function by activating calcium-dependent signaling pathways that interact with COG5's role in vesicular trafficking. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore leading to increased intracellular Ca2+, which can enhance COG5 activity by modulating calcium-dependent pathways that COG5 is involved in. | ||||||
Fusicoccin | 20108-30-9 | sc-200754 sc-200754A sc-200754B | 1 mg 5 mg 10 mg | $408.00 $2040.00 $4080.00 | 7 | |
Fusicoccin stabilizes the interaction between H+-ATPases and 14-3-3 proteins, potentially enhancing COG5 function by affecting vesicular transport mechanisms that COG5 is associated with. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels, which could indirectly enhance COG5 function by affecting Ca2+-dependent pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P enhances sphingosine kinase activity, potentially enhancing COG5 activity by modulating sphingolipid signaling pathways that intersect with COG5's role in vesicular trafficking. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can enhance COG5 function by altering PI3K/Akt signaling pathways, which may intersect with vesicle trafficking pathways involving COG5. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, which may enhance COG5 function by affecting the phosphorylation state of proteins involved in vesicle trafficking that COG5 is part of. | ||||||