CNTNAP3 Inhibitors
CNTNAP3 inhibitors are chemical compounds that target and inhibit the function of the CNTNAP3 protein, which is a member of the contactin-associated protein (CNTNAP) family. CNTNAP3 is a transmembrane protein predominantly expressed in the nervous system, where it plays a key role in mediating cell-cell interactions, particularly in neurons. It is part of the neurexin family and is involved in the organization of the nodes of Ranvier, specialized regions along axons that facilitate the rapid propagation of action potentials. CNTNAP3 contributes to maintaining the structural integrity of these nodes by interacting with other proteins involved in the insulation and conduction of nerve signals. Additionally, CNTNAP3 may participate in processes that influence neuronal communication and synaptic function.
Inhibitors of CNTNAP3 are important for understanding its specific role in neural development and the maintenance of neural circuitry. By inhibiting CNTNAP3, researchers can study how this protein influences the structure and function of the nervous system, particularly in the context of axonal organization and signal transmission. This inhibition can also provide insight into how CNTNAP3 interacts with other proteins in the extracellular matrix and how it contributes to the formation and maintenance of neuronal junctions. Furthermore, CNTNAP3 is implicated in the modulation of synaptic plasticity, making its inhibitors valuable tools for exploring its contribution to the fine-tuning of neural communication. Overall, inhibiting CNTNAP3 helps unravel the molecular mechanisms underlying neural connectivity and offers a deeper understanding of its role in the broader framework of nervous system function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clozapine | 5786-21-0 | sc-200402 sc-200402A sc-200402B sc-200402C | 50 mg 500 mg 5 g 10 g | $69.00 $364.00 $2500.00 $4100.00 | 11 | |
Clozapine, an atypical antipsychotic, acts as a direct inhibitor of CNTNAP3, influencing neuron-glial interactions. This inhibition disrupts the normal functioning of CNTNAP3 in cell recognition within the nervous system, potentially altering neural connectivity. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, a histone deacetylase inhibitor, serves as a direct CNTNAP3 inhibitor, affecting neuron-glial interactions. This disruption may impact cell recognition within the nervous system, elucidating a potential role in modulating neural plasticity. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin, an ATP synthase inhibitor, indirectly influences CNTNAP3 by affecting cellular energy homeostasis. This disruption could modulate neuron-glial interactions and alter the recognition of cells within the nervous system. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, serves as an indirect CNTNAP3 inhibitor by disrupting the PI3K signaling pathway. This interference impacts neuron-glial interactions, potentially influencing cell recognition within the nervous system. | ||||||
6-Aminonicotinamide | 329-89-5 | sc-278446 sc-278446A | 1 g 5 g | $156.00 $398.00 | 3 | |
6-Aminonicotinamide, an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), indirectly affects CNTNAP3 by modulating cellular NAD+ levels. This disruption may impact neuron-glial interactions and alter cell recognition within the nervous system. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074, a Raf-1 kinase inhibitor, indirectly influences CNTNAP3 by disrupting the Raf-1 signaling pathway. This interference may impact neuron-glial interactions and alter cell recognition within the nervous system. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082, an inhibitor of nuclear factor-kappa B (NF-κB), indirectly affects CNTNAP3 by modulating NF-κB signaling. This disruption may impact neuron-glial interactions and alter cell recognition within the nervous system. | ||||||
Mangostin | 6147-11-1 | sc-211773 | 10 mg | $245.00 | ||
Mangostin, a xanthone derivative, serves as an indirect CNTNAP3 inhibitor by modulating the Akt signaling pathway. This interference impacts neuron-glial interactions and alters cell recognition within the nervous system. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, indirectly influences CNTNAP3 by disrupting the PI3K signaling pathway. This interference impacts neuron-glial interactions, potentially altering cell recognition within the nervous system. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a c-Jun N-terminal kinase (JNK) inhibitor, indirectly affects CNTNAP3 by modulating the JNK signaling pathway. This disruption may impact neuron-glial interactions and alter cell recognition within the nervous system. | ||||||