CNPase Activators
CNPase activators represent a diverse group of chemicals that influence the function of CNPase indirectly by modulating related signaling pathways. Primarily, these activators function through the elevation of intracellular cyclic nucleotide levels (cAMP or cGMP), achieved by inhibiting specific phosphodiesterases or activating adenylate cyclase.
The increased levels of cAMP or cGMP lead to the activation of protein kinases such as PKA and PKG. These kinases play a crucial role in phosphorylating a variety of proteins, thereby influencing signaling cascades that intersect with the functional pathways of CNPase. The indirect activation of CNPase through these chemicals is pivotal, as it allows for the modulation of CNPase activity without directly interacting with the protein itself.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various proteins, indirectly influencing CNPase activity by modulating signaling pathways that intersect with CNPase function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Selective inhibitor of phosphodiesterase-4 (PDE4), elevates intracellular cAMP by preventing its breakdown. This elevation can activate PKA, subsequently impacting pathways that intersect with CNPase activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Synthetic catecholamine, activates beta-adrenergic receptors, leading to increased cAMP and PKA activation. This cascade can indirectly modulate CNPase activity through the phosphorylation of proteins in related pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, increases cAMP and cGMP by preventing their degradation. The resultant PKA and PKG activation may indirectly influence CNPase activity by modulating signaling pathways. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Phosphodiesterase-3 inhibitor, increases cAMP levels, leading to PKA activation. This can alter CNPase activity indirectly by affecting phosphorylation states of proteins within intersecting signaling pathways. | ||||||
Anagrelide hydrochloride | 58579-51-4 | sc-203513 sc-203513A | 10 mg 50 mg | $103.00 $587.00 | 1 | |
Another phosphodiesterase-3 inhibitor, raises cAMP levels, thereby activating PKA. This activation can indirectly modulate CNPase activity through the phosphorylation of related pathway proteins. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Phosphodiesterase-3 inhibitor, increases intracellular cAMP, leading to PKA activation. This can influence CNPase activity indirectly by modulating signaling pathways through protein phosphorylation. | ||||||
Enoximone | 77671-31-9 | sc-252775 sc-252775A | 10 mg 50 mg | $181.00 $728.00 | 1 | |
Selective phosphodiesterase-3 inhibitor, raises cAMP levels, activating PKA. This can indirectly affect CNPase activity by influencing the phosphorylation of proteins in related signaling pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Selective phosphodiesterase-5 inhibitor, increases cGMP levels, which can indirectly influence cAMP dynamics. The subsequent PKA and PKG activation can modulate CNPase activity through phosphorylation of proteins in associated pathways. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Phosphodiesterase-1 inhibitor, increases cAMP and cGMP levels, leading to PKA and PKG activation. This can indirectly affect CNPase activity through the modulation of signaling pathways via protein phosphorylation. | ||||||