ClpP Activators
ClpP activators are chemicals that modulate the activity of the ClpP protease, a key enzyme in protein degradation and quality control within cells. These activators do not necessarily bind directly to ClpP but influence its activity through various indirect mechanisms. For example, ADEP activates ClpP in bacterial cells by binding allosterically, leading to enhanced proteolytic activity. Other chemicals, such as mitochondrial function modulators (e.g., Valinomycin, CCCP, Oligomycin, Antimycin A) and inhibitors of the electron transport chain (e.g., Rotenone, Piericidin A), affect ClpP activity by altering mitochondrial dynamics and stress responses. This modulation is crucial in maintaining cellular homeostasis and responding to various stresses, including those induced by damaged or misfolded proteins.
Furthermore, chemicals that generate cellular stress, like Paraquat, or those affecting the proteostasis network, such as proteasome inhibitors (MG-132, Bortezomib), can indirectly influence ClpP activity. In bacterial cells, antibiotics like Chloramphenicol and Tetracycline can modulate ClpP activity by impacting bacterial protein synthesis and degradation pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Valinomycin indirectly influences ClpP activity by altering mitochondrial membrane potential, affecting mitochondrial ClpP function. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
CCCP disrupts mitochondrial membrane potential, indirectly affecting ClpP activity by uncoupling oxidative phosphorylation. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin indirectly influences ClpP activity in mitochondria by affecting ATP levels and mitochondrial function as an ATP synthase inhibitor. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A modulates ClpP activity indirectly by affecting mitochondrial energetics and stress response as an inhibitor of the mitochondrial electron transport chain. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Paraquat generates ROS, indirectly influencing ClpP activity by inducing cellular stress and affecting protein degradation pathways. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone, as a mitochondrial complex I inhibitor, indirectly affects ClpP activity through alterations in mitochondrial function and induced stress. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $291.00 | 24 | |
Piericidin A impacts ClpP activity indirectly by affecting mitochondrial energetics and stress pathways as a complex I inhibitor. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib might indirectly influence ClpP activity by altering cellular protein degradation pathways and stress responses as a proteasome inhibitor. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol indirectly affects ClpP activity in bacteria, impacting protein homeostasis and stress responses as an antibiotic. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline indirectly influences ClpP activity in bacteria by affecting protein synthesis and potentially altering protein degradation pathways. | ||||||