Date published: 2026-2-14

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CLCA3_Clac3 Inhibitors

CLCA3 (Calcium-activated chloride channel regulator 3) and Clac3 (Clara cell 10 kDa protein) inhibitors constitute a specialized class of chemical compounds that have attracted attention in the field of molecular biology and ion channel regulation research. CLCA3 and Clac3 are proteins involved in various physiological processes, including the regulation of chloride ion channels and mucus production in the airway epithelium. The term CLCA3_Clac3 inhibitors refers to a group of molecules meticulously designed to selectively target and modulate the activities of both CLCA3 and Clac3. These inhibitors serve as invaluable tools in laboratory investigations, enabling researchers to explore the intricate molecular functions and cellular processes associated with these proteins.

CLCA3_Clac3 inhibitors typically function by interfering with the roles of CLCA3 and Clac3 in chloride channel regulation, mucin secretion, and other cellular processes. This interference can lead to alterations in ion transport and mucin production, impacting various aspects of airway physiology and potentially other biological functions involving these proteins. Researchers employ CLCA3_Clac3 inhibitors to gain insights into the physiological roles and molecular interactions of CLCA3 and Clac3 within cells, aiming to advance our understanding of the fundamental mechanisms involved in ion channel regulation and mucus production in the airway epithelium. Through the study of CLCA3_Clac3 inhibitors, scientists seek to unravel the complexities of airway biology, ion transport, and the broader field of cellular and molecular biology, contributing to our knowledge of how these proteins influence respiratory and potentially other physiological processes.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cortisone

53-06-5sc-207455
5 g
$230.00
(0)

Cortisone may reduce the inflammatory response, possibly decreasing the expression of CLCA3, which is associated with mucous production.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

Dexamethasone is a glucocorticoid that can suppress inflammation and may downregulate genes like CLCA3 in airway epithelial cells.

Amiloride

2609-46-3sc-337527
1 g
$296.00
7
(1)

Amiloride is known to inhibit epithelial sodium channels and might indirectly reduce CLCA3 expression related to ion transport regulation.

Bumetanide (Ro 10-6338)

28395-03-1sc-200727
sc-200727A
1 g
5 g
$109.00
$228.00
9
(1)

Bumetanide inhibits the Na-K-Cl cotransporter and may reduce chloride secretion, potentially decreasing CLCA3 expression.

Hydrochlorothiazide

58-93-5sc-207738
sc-207738A
sc-207738B
sc-207738C
sc-207738D
5 g
25 g
50 g
100 g
250 g
$55.00
$240.00
$333.00
$562.00
$988.00
(0)

By inhibiting the Na-Cl symporter, hydrochlorothiazide could influence chloride ion homeostasis and CLCA3 expression.

Propranolol

525-66-6sc-507425
100 mg
$180.00
(0)

As a beta-blocker, propranolol may affect adrenergic signaling, which could potentially decrease CLCA3 expression linked to signaling cascades.

Sulindac

38194-50-2sc-202823
sc-202823A
sc-202823B
1 g
5 g
10 g
$32.00
$86.00
$150.00
3
(1)

Sulindac may affect various signaling pathways, potentially leading to decreased CLCA3 expression.

Furosemide

54-31-9sc-203961
50 mg
$41.00
(1)

Furosemide is a loop diuretic that inhibits NKCC2 and could indirectly decrease CLCA3 expression associated with ion transport.

Acetazolamide

59-66-5sc-214461
sc-214461A
sc-214461B
sc-214461C
sc-214461D
sc-214461E
sc-214461F
10 g
25 g
100 g
250 g
500 g
1 kg
2 kg
$81.00
$177.00
$434.00
$541.00
$883.00
$1479.00
$2244.00
1
(1)

Acetazolamide inhibits carbonic anhydrase, which could affect chloride transport and potentially CLCA3 expression.

Omeprazole

73590-58-6sc-202265
50 mg
$67.00
4
(1)

Omeprazole, a proton pump inhibitor, could indirectly affect the ion channels and transporters, possibly reducing CLCA3 expression.