CIB3 Inhibitors

CIB3 Inhibitors encompass a range of chemical compounds that indirectly inhibit the functional activity of the calcium and integrin-binding family member 3 (CIB3) protein. These compounds are not CIB3 inhibitors themselves but are involved in various cellular signaling pathways and processes that CIB3 may be a part of.

For instance, Wortmannin and LY294002, as PI3K inhibitors, prevent the phosphorylation of AKT, a serine/threonine-specific protein kinase that playsa crucial role in the PI3K/AKT/mTOR signaling pathway. This pathway is integral for processes such as cell growth, survival, metabolism, and proliferation. If CIB3 is involved in this pathway or its activity is modulated by AKT, the inhibition of PI3K and subsequent reduction in AKT phosphorylation by compounds like Wortmannin and LY294002 could result in decreased CIB3 activity.