CHST13 Activators
Carbohydrate (Chondroitin 4) Sulfotransferase 13, abbreviated as CHST13, is an enzyme with a specific biological role in the modification of chondroitin. Chondroitin sulfate is a vital component of the extracellular matrix found within connective tissues, and its sulfation is essential for maintaining the structural integrity and function of various tissues. CHST13 facilitates the transfer of sulfate groups to the chondroitin molecule, which alters its interaction with other biomolecules, affecting tissue elasticity and cell adhesion properties. As part of the family of carbohydrate sulfotransferases, CHST13 contributes to the complexity and diversity of the glycosaminoglycan landscape within the human body. The precise regulation of CHST13 is crucial, as it ensures the proper balance and dynamics of chondroitin sulfation, which is integral to the normal physiological function of multiple organ systems.
The expression of CHST13 can be influenced by a range of chemical compounds that act as activators, each interacting with cellular mechanisms to upregulate gene expression. Compounds such as retinoic acid, a known activator of retinoid receptors, can lead to the transcriptional activation of genes by binding to specific elements within the promoter regions of target genes. Similarly, forskolin, through its ability to raise intracellular cAMP levels, may activate protein kinase A, leading to the enhanced transcription of genes, including those encoding sulfotransferases like CHST13. Histone deacetylase inhibitors, like trichostatin A and sodium butyrate, can affect the chromatin architecture, increasing the accessibility of transcription factors to the DNA, and potentially promoting the expression of CHST13. Additionally, compounds such as beta-estradiol, which interacts with estrogen receptors, can stimulate the transcription of a repertoire of genes by acting as a transcription factor upon receptor binding. These activators, among others, are part of the complex regulatory network that can influence the levels of CHST13, reflecting the intricacies of gene expression modulation in human physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid serves as an activator for retinoid receptors, which can upregulate gene transcription in a cell-type-specific manner, potentially stimulating the expression of enzymes involved in extracellular matrix modification such as CHST13. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferase, leading to hypomethylation of DNA and consequent transcriptional activation of certain genes. This demethylation can potentially stimulate the expression of CHST13 by increasing the accessibility of its promoter region to transcription factors. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, resulting in elevated cAMP levels that can activate protein kinase A (PKA) and lead to the transcriptional activation of numerous genes. This signal transduction cascade may stimulate CHST13 expression as part of a broader response to hormonal stimuli. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone binds to glucocorticoid receptors and can initiate transcriptional activation of target genes through receptor dimerization and binding to glucocorticoid response elements. This process could include the upregulation of genes like CHST13 involved in cellular stress responses. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases, which increases the acetylation of histones, causing the chromatin structure to become more open and accessible for transcriptional machinery, potentially leading to the increased expression of CHST13. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, an HDAC inhibitor, can enhance histone acetylation, promoting a transcriptionally active chromatin state. This can lead to the upregulation of various genes, including possibly CHST13, by allowing transcription factors greater access to DNA. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide can serve as a signaling molecule, activating pathways that respond to oxidative stress. This can lead to the upregulation of antioxidant defense genes and may include the induction of CHST13 as part of the cellular adaptive response. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol binds estrogen receptors, which can then act as transcription factors to increase the expression of a range of genes associated with cell growth and proliferation, and this may stimulate the expression of genes like CHST13 that are involved in cell structure and function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium ions can inhibit glycogen synthase kinase-3, leading to the stabilization of transcription factors such as β-catenin, which may in turn lead to the increased expression of target genes, potentially including CHST13 as part of Wnt signaling pathway responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which has a role in various signal transduction pathways. Its activation can lead to the altered transcription and increased expression of genes involved in cell differentiation and proliferation, possibly leading to the induction of CHST13. | ||||||