CHMP7 Inhibitors
Chemical inhibitors of CHMP7 can affect its function in various cellular processes including endosomal sorting, membrane remodeling, and nuclear envelope reformation. Alloxazine interferes with the ESCRT-III complex assembly, of which CHMP7 is a crucial component, by hindering the polymerization and membrane remodeling activities that are essential for the complex's function. Aurintricarboxylic Acid disrupts CHMP7's interaction with nucleic acids, which is necessary for its role in chromatin organization and nuclear envelope reformation. Bafilomycin A1's inhibition of vacuolar H+ ATPase can lead to dysregulation of endosomal acidification, thus affecting the endosomal sorting functions involving CHMP7. Ebselen, through its redox-modulating activities, can alter the assembly of the ESCRT-III complex, thereby impairing CHMP7's function in membrane remodeling. Dynasore's inhibition of GTPase activity affects dynamin-related proteins, which play a role in the membrane scission events that are supported by CHMP7.
Furthermore, Mitoxantrone, by intercalating into DNA, can impede the DNA-protein interactions necessary for CHMP7's function during mitotic exit. Myricetin inhibits phosphoinositide 3-kinases that participate in signaling pathways regulating membrane trafficking events in which CHMP7 is involved, thereby affecting its function. Neomycin, by binding to phospholipids, can disrupt membrane integrity and consequently impair CHMP7's role in endosomal sorting. Nocodazole disrupts microtubule dynamics, essential for CHMP7's proper localization and function in cellular division and membrane reformation. Okadaic Acid alters the phosphorylation state of proteins within the ESCRT pathway, influencing CHMP7's role in the complex. U18666A induces intracellular cholesterol accumulation, altering membrane properties and subsequently affecting CHMP7's recruitment and function in membrane remodeling processes. Lastly, zinc ions can bind to and alter the function of metalloproteins and enzymes, potentially disrupting the enzymatic activities required by CHMP7 to fulfill its role in endosomal sorting and membrane fusion.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
Aurintricarboxylic Acid can bind to nucleic acids and prevent protein-nucleic acid interactions, which could disrupt the function of CHMP7, as it has been implicated in nuclear envelope reformation and chromatin organization. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a vacuolar H+ ATPase inhibitor that can disrupt endosomal acidification, a process that CHMP7 supports through its role in endosomal sorting complexes required for transport. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen, a selenium-containing compound, can inhibit various enzymes that regulate redox states, potentially affecting the assembly of the ESCRT-III complex and thus inhibiting CHMP7's function in membrane remodeling. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that can impede the function of dynamin-related proteins, which are involved in membrane scission events that CHMP7 is known to support. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone can intercalate into DNA and disrupt DNA-protein interactions, which may interfere with the role of CHMP7 in nuclear envelope reformation during mitotic exit. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $97.00 $188.00 $260.00 $510.00 $1022.00 | 3 | |
Myricetin is a flavonoid that can inhibit phosphoinositide 3-kinases, which are involved in signaling pathways that regulate membrane trafficking events in which CHMP7 participates. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
Neomycin, an aminoglycoside antibiotic, can bind to phospholipids and disrupt membrane integrity, potentially impairing CHMP7's function in endosomal sorting and membrane remodeling. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule depolymerizing agent that can disrupt microtubule dynamics, which are essential for the proper localization and function of CHMP7 in cellular division and membrane reformation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, which can influence the phosphorylation state of proteins involved in the ESCRT pathway, thus affecting CHMP7's role in the complex. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
U18666A can induce intracellular cholesterol accumulation, which alters membrane properties and can affect the recruitment and function of CHMP7 in membrane remodeling processes. | ||||||