CHD2 Inhibitors
CHD2 is intimately involved in the complex dynamics of chromatin remodeling, a process essential for various DNA-templated activities. CHD2 Inhibitors typically targets mechanisms or associated factors of chromatin alteration, rather than CHD2 directly.
UNC1999 and GSK126, on the other hand, are EZH2 inhibitors, influencing the methylation state of histones which in turn can affect chromatin remodelers like CHD2. JIB-04 targets the JmjC domain of histone demethylases, offering another route to modify the chromatin landscape. BIX-01294 is particularly interesting as it targets G9a histone methyltransferase, altering histone methylation, a key determinant in chromatin structure. Lastly, PFI-1 and I-BET151 are BET bromodomain inhibitors, disrupting the recognition of acetylated histones, which can indirectly modulate the chromatin-remodeling activities of proteins like CHD2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
EZH2 inhibitor, affecting the methylation state of histones. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
Pan-Jumonji inhibitor targeting JmjC histone demethylases, influencing chromatin state. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
EZH2 inhibitor impacting histone methylation and chromatin structure. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
G9a histone methyltransferase inhibitor, affecting histone methylation. | ||||||
PFI-1 | 1403764-72-6 | sc-478504 | 5 mg | $98.00 | ||
BET bromodomain inhibitor affecting recognition of acetylated histones. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
BET bromodomain inhibitor impacting the interaction with acetylated histones. | ||||||