CGREF1 inhibitors are a class of compounds that specifically target and inhibit the activity of the CGREF1 (Cell Growth Regulator with EGF-like domain 1) protein, which is known to play a role in regulating cellular growth and differentiation. CGREF1 is thought to be involved in intercellular communication, influencing how cells respond to growth signals and environmental cues. By inhibiting CGREF1, these compounds disrupt its ability to modulate these processes, allowing researchers to investigate the protein's exact role in cellular signaling and growth regulation. Inhibition of CGREF1 can lead to altered cell communication and regulatory dynamics, making these inhibitors useful tools in exploring the molecular mechanisms that underlie cell proliferation, differentiation, and maintenance of cellular homeostasis.
The mechanism of action for CGREF1 inhibitors involves binding to functional sites on the protein, thereby preventing its interaction with other signaling molecules or disrupting its role in cell signaling pathways. Researchers use CGREF1 inhibitors to study the protein's involvement in key biological processes, particularly those related to cellular growth regulation and response to external stimuli. These inhibitors are valuable for examining how CGREF1 controls the balance between cellular growth and differentiation, as well as its influence on maintaining proper cellular function. By understanding the effects of CGREF1 inhibition, scientists can gain deeper insights into the protein's role in regulating complex intracellular networks and its broader impact on cell behavior and the coordination of growth-related processes across different tissues or environments.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can influence various signaling pathways, possibly affecting the phosphorylation state of CGREF1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A SERCA pump inhibitor that can disrupt calcium homeostasis, potentially altering CGREF1 activity if it relies on calcium signaling. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A calcium chelator that can attenuate intracellular calcium levels, potentially affecting CGREF1 function if it is calcium-dependent. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
A FGFR inhibitor that can affect growth factor signaling, possibly impacting CGREF1 if it is part of this pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-beta/Activin/Nodal pathway that can alter cellular differentiation, potentially affecting CGREF1 if it is involved in this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can affect multiple signaling pathways, potentially influencing CGREF1 if it is involved in PI3K/Akt signaling. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
An IP3 receptor blocker that can influence calcium release from the endoplasmic reticulum, potentially affecting CGREF1 if it is calcium-dependent. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
A calmodulin antagonist that can interfere with calcium signaling, potentially influencing CGREF1 if it interacts with calcium-binding proteins. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
A CaMKII inhibitor that can affect calcium-dependent signaling pathways, potentially impacting CGREF1 if it is part of such pathways. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
An inhibitor of non-muscle myosin II ATPase activity, which can affect cytoskeleton dynamics, possibly impacting CGREF1 if it is associated with cytoskeletal elements. | ||||||