CES3 Inhibitors
CES3 inhibitors are a class of compounds that specifically inhibit carboxylesterase 3 (CES3), an enzyme from the carboxylesterase family responsible for hydrolyzing ester-containing molecules. CES3 plays a significant role in the metabolism of lipids and other esterified substrates within the body, breaking down ester bonds in various compounds such as cholesterol esters and xenobiotics. The enzyme's activity is essential in maintaining cellular lipid homeostasis, processing esterified compounds into their corresponding alcohols and acids. By inhibiting CES3, these compounds disrupt the enzyme's catalytic activity, leading to changes in the metabolism of lipids and other esters, affecting their normal breakdown and utilization in the cell.
The mechanism of CES3 inhibitors typically involves blocking the enzyme's active site, which prevents CES3 from binding to its ester substrates. This inhibition can slow down or halt the hydrolysis of esters, allowing researchers to observe the accumulation of specific substrates and explore how CES3 contributes to overall lipid and ester metabolism. CES3 inhibitors are valuable tools in research focusing on the enzyme's role in biochemical processes related to fat storage, energy metabolism, and detoxification. By modulating CES3 activity, scientists can investigate how carboxylesterase enzymes regulate ester processing, lipid mobilization, and cellular metabolic balance. This provides key insights into the functional significance of CES3 in maintaining the proper regulation of esterified compounds in different biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can disrupt hormonal balance, specifically by mimicking estrogen, which could decrease CES3 expression by interfering with the normal hormonal regulation of gene transcription in the liver. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase, leading to a more open chromatin structure and potentially resulting in the decreased transcription of the CES3 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can induce DNA demethylation, which might reduce CES3 expression by altering the methylation status of its gene promoter, thereby changing the binding affinity of transcription factors. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium (meta)arsenite may initiate oxidative stress responses, which could downregulate CES3 expression as the cell shifts its priorities to mitigate oxidative damage. | ||||||
Bis(2-ethylhexyl) phthalate | 117-81-7 | sc-254975 | 1 g | $56.00 | 2 | |
Bis(2-ethylhexyl) phthalate could decrease CES3 expression by mimicking or blocking hormone signals, leading to altered transcriptional activity of genes involved in xenobiotic metabolism. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may reduce CES3 expression by binding to its specific nuclear receptors, which can repress or activate gene transcription depending on the target genes and the presence of co-repressors or co-activators. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could decrease CES3 expression as a consequence of its action as a dihydrofolate reductase inhibitor, disrupting folate metabolism and DNA synthesis, and thereby affecting cell proliferation and gene expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may downregulate CES3 expression by activating the NRF2 pathway, which can alter the transcription of a wide array of genes, including those involved in phase II detoxification. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium chloride could reduce CES3 expression by interfering with essential metal ion homeostasis in the cell, leading to altered transcription factor activity and gene expression. | ||||||
Chlorpyrifos | 2921-88-2 | sc-217887 | 250 mg | $92.00 | ||
Chlorpyrifos may indirectly inhibit CES3 expression through its role as a cholinesterase inhibitor, which can induce a broad spectrum of biochemical and physiological responses including the dysregulation of gene transcription. | ||||||