CENP-R Activators

The chemical class termed CENP-R Activators consists of a range of compounds primarily characterized by their ability to modify epigenetic markers and chromatin architecture, which in turn can lead to the enhanced expression of CENP-R. The compounds listed above are known to act on various molecular targets such as DNA methylation, histone acetylation, and chromatin compaction, which are fundamental processes governing gene expression.

In the context of CENP-R, these compounds primarily function by remodeling the chromatin landscape around the centromeric regions where CENP-R is located, either by inhibiting the enzymes responsible for maintaining a repressive chromatin environment or by actively promoting a transcriptionally favorable chromatin state. For instance, histone deacetylase inhibitors like Trichostatin A, Vorinostat, Sodium butyrate, and Valproic acid lead to an accumulation of acetylated histones, associated with an open chromatin conformation and active gene expression. Similarly, compounds like 5-Aza-2'-deoxycytidine and Decitabine induce DNA hypomethylation, which can activate the transcription of genes that are otherwise silenced by DNA methylation