CDK2AP1 Activators
CDK2AP1 activators belong to a distinctive class of chemical compounds that exert their influence on the cell cycle through modulation of the Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1). CDK2AP1, also known as p12, is a crucial regulatory protein involved in cell cycle progression and is implicated in the control of various cellular processes. The activators function by enhancing the activity or expression of CDK2AP1, thereby influencing downstream cellular events governed by this protein.
At the molecular level, CDK2AP1 activators interact with specific binding sites on the CDK2AP1 molecule, eliciting conformational changes that augment its functional capabilities. By promoting the stability or activity of CDK2AP1, these compounds play a pivotal role in regulating the transition between different phases of the cell cycle, such as G1 to S phase. The modulation of CDK2AP1 activity can impact the assembly and activation of cyclin-dependent kinase complexes, influencing cell proliferation, differentiation, and apoptosis. As research in this field progresses, elucidating the intricate mechanisms by which CDK2AP1 activators operate may provide valuable insights into cellular regulation and contribute to the development of novel strategies for influencing cellular behavior in various physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
A selective inhibitor of several CDKs, olomoucine can upregulate CDK2AP1's role in the cell cycle and DNA repair by reducing competitive CDK activities. | ||||||
PD 0332991 Isethionate | 827022-33-3 | sc-478943 | 1 mg | $300.00 | ||
A potent and selective inhibitor of CDK4/6, PD 0332991 enhances CDK2AP1 function by reducing phosphorylation of proteins that compete with CDK2AP1, thus favoring its activity in cellular processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can enhance CDK2AP1 activity by promoting a more relaxed chromatin structure, which could facilitate the engagement of CDK2AP1 in transcription regulation and DNA repair mechanisms. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, 5-Azacytidine can lead to demethylation of the CDK2AP1 promoter, potentially enhancing its expression and thus its protein activity in cell cycle regulation and DNA repair. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, vorinostat may increase the activity of CDK2AP1 by causing chromatin remodeling that favors the expression of genes involved in the regulation of the cell cycle and DNA repair processes, where CDK2AP1 is a critical player. | ||||||
PHA-848125 | 802539-81-7 | sc-364581 sc-364581A | 5 mg 10 mg | $304.00 $555.00 | ||
A multi-kinase inhibitor, milciclib can enhance CDK2AP1 activity by modulating various CDKs and affecting cell cycle progression, which can indirectly promote the activity of CDK2AP1 in processes like DNA replication fidelity and repair mechanisms. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
By inhibiting CDK2, CDK7, and CDK9, SNS-032 may indirectly enhance CDK2AP1 activity due to the interconnectedness of cell cycle regulation and DNA repair systems where CDK2AP1 functions, thus potentially increasing its role in maintaining genomic integrity. | ||||||