Cdc42EP5 Activators
Cdc42EP5 activators represent a diverse array of small molecules that intricately modulate the activation of Cdc42EP5, a Rho GTPase effector protein. Notably, SecinH3 directly activates Cdc42EP5 by inhibiting the ARF GTPase-activating protein, resulting in sustained Cdc42 activation. This sustained activation promotes cytoskeletal rearrangements and cellular processes associated with Cdc42EP5-mediated signaling. Conversely, ML141, NSC 23766, CASIN, ZCL278, AZA1, ITX3, CID 2950007, and ACHP indirectly activate Cdc42EP5 by preventing Cdc42 inactivation or disrupting its interactions with downstream effectors. These disruptions lead to sustained Cdc42 activation, enhancing Cdc42EP5 functions and influencing cellular processes related to Cdc42-mediated signaling.
The chemical class of Cdc42EP5 activators, represented by these small molecules, plays a crucial role in finely tuning the activity of Cdc42EP5 within the cellular context. These activators not only provide tools for experimental manipulation of Cdc42EP5 function but also shed light on the intricate regulatory mechanisms governing Cdc42EP5-mediated cellular responses. Their ability to modulate Cdc42, a key regulator of cytoskeletal dynamics and cellular signaling,
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3, a small molecule, directly activates Cdc42EP5 by inhibiting the ARF GTPase-activating protein. This inhibition leads to the sustained activation of Cdc42, promoting cytoskeletal rearrangements and cellular processes associated with Cdc42EP5-mediated signaling. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC 23766 indirectly activates Cdc42EP5 by blocking Cdc42 binding to its guanine nucleotide exchange factors (GEFs). This disruption results in sustained Cdc42 activation, enhancing Cdc42EP5-mediated cellular processes linked to Cdc42 signaling. | ||||||
AZA1 | 1071098-42-4 | sc-507497 | 10 mg | $600.00 | ||
AZA1, a selective Cdc42 inhibitor, indirectly activates Cdc42EP5 by preventing Cdc42 inactivation. The sustained Cdc42 activation enhances Cdc42EP5 functions, influencing cellular processes related to Cdc42-mediated signaling. | ||||||
ITX 3 | 347323-96-0 | sc-295214 sc-295214A | 10 mg 50 mg | $145.00 $615.00 | ||
ITX3 indirectly activates Cdc42EP5 by disrupting Cdc42 interaction with its downstream effectors. This disruption results in sustained Cdc42 activation, enhancing Cdc42EP5-mediated cellular processes associated with Cdc42 signaling. | ||||||