CD160 Inhibitors

CD160 inhibitors are a class of chemical compounds that primarily target and modulate the CD160 protein, a cell surface glycoprotein belonging to the immunoglobulin superfamily. CD160, also known as Natural Killer Cell Receptor BY55 (NKp46), is expressed on various immune cells, including natural killer (NK) cells, T cells, and some subsets of B cells. Its role in the immune system revolves around regulating immune responses, particularly in the context of cytotoxicity and cytokine production. CD160 inhibitors are designed to interact with CD160, altering its activity or signaling pathways to influence immune cell function.

These inhibitors work through different mechanisms, such as blocking CD160's binding to its ligand HVEM (Herpesvirus Entry Mediator) or inhibiting downstream signaling pathways activated upon CD160 engagement. By modulating CD160, these compounds can potentially impact immune responses in various ways, including regulating the cytotoxicity of NK cells and the production of pro-inflammatory cytokines by T cells. The development and study of CD160 inhibitors are particularly relevant in the field of immunology, where a deeper understanding of immune cell regulation can contribute to insights into immune-related diseases.