CCDC90A Inhibitors
Chemical inhibitors of CCDC90A function largely by interfering with its role in the mitochondrial calcium uniporter (MCU) complex. Ru360, for instance, is a known specific inhibitor of the MCU complex, directly binding to the MCU and blocking the calcium uptake into mitochondria. By obstructing this pathway, Ru360 functionally inhibits CCDC90A's ability to regulate mitochondrial calcium ion transport. Ruthenium Red operates similarly by preventing mitochondrial calcium uptake, which is an essential function of the CCDC90A within the MCU complex. Furthermore, compounds like KB-R7943 and CGP-37157, though primarily targeting the Na+/Ca2+ exchangers, can indirectly limit the functionality of CCDC90A. KB-R7943 alters intracellular calcium concentration, which is integral to CCDC90A's operation within the MCU, while CGP-37157 by inhibiting the mitochondrial Na+/Ca2+ exchanger can increase mitochondrial calcium, potentially overloading the system and thereby reducing CCDC90A's ability to regulate additional calcium influx.
Other inhibitors such as Gadolinium Chloride and Lanthanum(III) chloride act as general calcium channel blockers, which can indirectly impact CCDC90A by constraining the very calcium fluxes that CCDC90A is designed to mediate in mitochondrial spaces. Similarly, calcium channel blockers like Verapamil, Diltiazem, Nifedipine, and Amlodipine, traditionally used to inhibit L-type calcium channels at the plasma membrane, can also impact intracellular calcium levels, which in turn can affect the mitochondrial calcium homeostasis that CCDC90A helps to maintain. Additionally, 2-APB, an inhibitor of IP3 receptors, modulates the store-operated calcium entry, thereby indirectly influencing CCDC90A by altering intracellular calcium signaling. Lastly, SKF-96365, which inhibits receptor-mediated calcium entry and store-operated calcium channels, can also impact CCDC90A by changing the calcium dynamics within the mitochondria where CCDC90A operates. Each of these chemicals can functionally inhibit CCDC90A by targeting different aspects of calcium regulation and transport, thereby influencing the protein's activity within the mitochondrial environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is known to inhibit mitochondrial calcium uptake. As CCDC90A is involved in the mitochondrial calcium uniporter complex, the inhibition of calcium uptake by Ruthenium Red consequently inhibits the function of CCDC90A by preventing its interaction with calcium ions. | ||||||
KB-R7943 MESYLATE | 182004-65-5 | sc-202681 | 10 mg | $157.00 | 4 | |
KB-R7943 is an inhibitor of the reverse mode of the Na+/Ca2+ exchanger and can indirectly inhibit CCDC90A by altering the intracellular calcium concentration, which is crucial for the proper functioning of the mitochondrial calcium uniporter where CCDC90A operates. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $113.00 $454.00 | 3 | |
CGP-37157 is an inhibitor of the mitochondrial Na+/Ca2+ exchanger. By inhibiting this exchanger, it can increase mitochondrial calcium levels, which in turn can inhibit CCDC90A by effectively reducing its capacity to regulate additional calcium influx through the mitochondrial calcium uniporter. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $150.00 $350.00 | 4 | |
Gadolinium Chloride is a blocker of calcium channels. By inhibiting calcium channels, it can indirectly inhibit CCDC90A by reducing calcium fluxes that CCDC90A is supposed to mediate in mitochondria. | ||||||
Lanthanum(III) chloride | 10099-58-8 | sc-257661 | 10 g | $88.00 | ||
Lanthanum(III) chloride is a general blocker of calcium channels. By blocking calcium channels, it can indirectly inhibit CCDC90A by minimizing the calcium entry that CCDC90A regulates in the mitochondrial matrix. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can inhibit L-type calcium channels. While its primary action is at the plasma membrane, it can also reduce mitochondrial calcium levels, thereby indirectly affecting the function of CCDC90A in mitochondrial calcium uptake. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, another blocker of L-type calcium channels, can indirectly inhibit CCDC90A by decreasing calcium influx into cells and thereby modulating the mitochondrial calcium levels that CCDC90A helps to regulate. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is an L-type calcium channel blocker that can indirectly inhibit CCDC90A by lowering cellular calcium influx, which in turn affects mitochondrial calcium levels and CCDC90A's functional role in the mitochondrial calcium uniporter complex. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine, also a calcium channel blocker, can reduce calcium entry into cells and subsequently affect mitochondrial calcium levels, indirectly inhibiting the role of CCDC90A in mitochondrial calcium uptake. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB inhibits IP3 receptors and can also modulate store-operated calcium entry. Through these actions, it can indirectly inhibit CCDC90A by altering the intracellular calcium signaling that is necessary for the proper function of the mitochondrial calcium uniporter complex that includes CCDC90A. | ||||||