CCDC7 Activators
CCDC7 Activators encompass a suite of chemical compounds that indirectly potentiate the functional activity of CCDC7 through a myriad of signaling pathways. Compounds such as Forskolin and IBMX enhance CCDC7's activity by increasing intracellular cAMP, which in turn activates PKA, a kinase that could phosphorylate proteins interacting with CCDC7, thus facilitating its functional role. Similarly, PMA activates PKC, which has a diverse range of substrates, some of which may modulate the CCDC7-related pathways. The increase in intracellular calcium levels by compounds like A23187 and Ionomycin triggers calcium-dependent signaling cascades that could positively influence CCDC7's role within the cell. Spermine, with its ability to interact with ion channels, and LY294002, a PI3K inhibitor, manipulate intracellular signaling in a manner that could result in the enhancement of CCDC7's activity.
The activity of CCDC7 is further modulated by chemicals that impact MAPK signaling. Both U0126 and PD98059, as inhibitors of MEK1/2, and SB203580, a p38 MAPK inhibitor, can shift the balance of cellular signaling, potentially leading to an upregulation of pathways that involve CCDC7. The ROCK inhibitor Y-27632 might enhance CCDC7's activity by affecting the cytoskeleton and related signaling, while Epigallocatechin gallate (EGCG) could influence CCDC7 activity by inhibiting various protein kinases that are part of CCDC7's signaling network. These diverse chemical activators of CCDC7, through their targeted effects on cellular signaling pathways, bolster the enhancement of CCDC7-mediated functions without directly altering itsexpression levels or requiring direct binding to the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that activates adenylyl cyclase, leading to increased levels of cAMP. Elevated cAMP can activate PKA, which may phosphorylate substrates that interact with CCDC7, thus enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a diacylglycerol analog that activates protein kinase C (PKC). Activated PKC can phosphorylate and alter the function of proteins involved in the pathway with CCDC7, potentially enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, which increases cAMP levels by preventing its degradation, thereby possibly enhancing pathways that interact with CCDC7. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, thus activating calcium-dependent signaling pathways that could upregulate CCDC7's functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium concentration, which may enhance CCDC7 activity through calcium-mediated signaling pathways. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can modulate ion channels and may influence signaling pathways that involve CCDC7, thus having the potential to enhance its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter signaling downstream of PI3K, potentially resulting in the enhancement of CCDC7 activity by modulating interacting pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which could lead to the alteration of MAPK pathway signaling, potentially enhancing the activity of CCDC7 by shifting the signaling equilibrium. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that could modify the MAPK pathway and indirectly enhance the activity of CCDC7 by influencing the cellular signaling network. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that may indirectly enhance CCDC7 activity by altering MAPK/ERK pathway signaling dynamics. | ||||||