CCDC151 Inhibitors

CCDC151 Inhibitors are essentially compounds that affect the ciliogenesis pathway, in which CCDC151 plays a crucial role. Rapamycin, a well-known mTOR inhibitor, suppresses mTORC1 signaling thereby hindering protein synthesis and cellular growth processes that are essential for ciliogenesis. Since CCDC151 is implicated in ciliogenesis, the presence of Rapamycin leads to decreased functional activity of CCDC151 through its action on mTORC1. Other inhibitors, such as LY294002 and Wortmannin, target PI3K, a kinase upstream of mTOR signaling. Inhibition of PI3K consequently leads to reduced AKT phosphorylation and mTOR activity, implicating a decrease in CCDC151 activity due to the impaired ciliogenesis pathway.

Moreover, compounds like Torin 1, AZD8055, and PP242, which are selective mTOR inhibitors, exert a similar influence on ciliogenesis and, consequently, on CCDC151 activity. The effectiveness of these inhibitors stems from their ability to disrupt the mTOR signaling pathway, thereby affecting the assembly and maintenance of cilia, processes in which CCDC151 is presumed to be involved.