Date published: 2026-4-1

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CCDC127 Inhibitors

CCDC127 inhibitors encompass a spectrum of chemical entities that modulate various biochemical pathways, ultimately leading to decreased functional activity of CCDC127. Kinase inhibitors, for instance, impede phosphorylation events crucial for CCDC127's interaction with other proteins, thereby perturbing its functional integrity. Additionally, compounds that target the phosphoinositide 3-kinase (PI3K) signaling pathway can alter actin dynamics, a structural and functional underpinning of many cellular processes, potentially impacting CCDC127's role within the cell. Disruption of the mammalian target of rapamycin (mTOR) signaling, an important regulator of cell growth and proliferation, also indirectly affects the cellular environment in which CCDC127 operates, attenuating its activity. Similarly, the inhibition of histone deacetylases can lead to broad changes in chromatin structure and gene expression that might impinge upon the pathways involving CCDC127. Furthermore, agents that interfere with the MAPK/ERK pathway can modify the regulatory milieu that CCDC127 is a part of, while inhibitors of vesicle trafficking can affect its localization and interactivity if CCDC127 is associated with membrane dynamics. Energy deprivation within the cell, triggered by glycolysis inhibitors, can also lead to a decrease in CCDC127's functional activity if its operation is energy contingent. Lastly, interference in the cell cycle regulation by inhibiting cyclin-dependent kinases or disrupting the mevalonate pathway, vital for the prenylation of small GTPases, could indirectly hinder CCDC127's activity.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

A potent kinase inhibitor that targets a wide range of kinases. Inhibition of these kinases can prevent phosphorylation events that are essential for CCDC127 function and interaction with other proteins, leading to its functional inhibition.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

A specific inhibitor of phosphoinositide 3-kinases (PI3K). PI3K signaling is crucial for many cellular processes, and by inhibiting this pathway, downstream effects on the actin cytoskeleton may occur, which can indirectly inhibit CCDC127's cellular functions if they are reliant on actin dynamics.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

An mTOR inhibitor that disrupts the mTOR signaling pathway, which is involved in cell growth and proliferation. By inhibiting mTOR, the cellular context in which CCDC127 operates could be altered, leading to a decrease in its functional activity.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

A histone deacetylase inhibitor that changes chromatin structure and gene expression. Although not directly affecting CCDC127, the altered gene expression could influence the cellular pathways and functions CCDC127 is involved in, thus indirectly inhibiting its functional activity.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

An immunosuppressant that inhibits calcineurin. By inhibiting calcineurin, Cyclosporin A can alter T-cell activation pathways, potentially affecting CCDC127's role if it is involved in immune cell function or signaling.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

A PI3K inhibitor similar to Wortmannin, which can also lead to alterations in the actin cytoskeleton and affect cellular functions that CCDC127 may be a part of, thereby indirectly inhibiting its activity.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

An inhibitor of MEK, which is a part of the MAPK/ERK pathway. By inhibiting MEK, PD 98059 can downregulate the MAPK/ERK signaling, potentially impacting the regulatory environment of CCDC127 and its associated cellular processes.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

An inhibitor of ADP-ribosylation factor (ARF), which is involved in vesicle trafficking. Disruption of vesicle trafficking could impact the localization and function of CCDC127 if it is associated with such processes.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

A selective inhibitor of both MEK1 and MEK2, which are upstream of ERK in the MAPK pathway. U0126's inhibition of this pathway can have downstream effects on cellular functions that CCDC127 may be involved with, leading to its inhibition.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$70.00
$215.00
26
(2)

A glycolysis inhibitor that mimics glucose but cannot be fully utilized in the glycolytic pathway, leading to energy depletion in the cell. If CCDC127's function is energy-dependent, this energy depletion could result in the inhibition of its activity.