CCDC103 Inhibitors
CCDC103 inhibitors can work by disrupting cellular functions such as the actin cytoskeleton dynamics, microtubule polymerization, intracellular trafficking, cell cycle progression, and signaling pathways like Wnt, mTOR, and ROCK. For instance, chemicals that interfere with the GSK-3β enzyme, such as Lithium Chloride, can destabilize the Wnt signaling pathway, which is known to play a pivotal role in ciliogenesis, potentially leading to altered ciliary function and indirectly affecting CCDC103.
Similarly, compounds like Rapamycin, which inhibit mTOR, can result in shorter or dysfunctional cilia, implicating an indirect effect on CCDC103's role within the cilia. Other compounds, like Cytochalasin D and Y-27632, target the cytoskeleton, which is the structural framework for cilia assembly, thus potentially affecting the incorporation or function of CCDC103. The overall effect of these inhibitors is to disrupt processes critical for the proper formation and maintenance of cilia, thereby affecting the functional context in which CCDC103 operates.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β leading to the stabilization of β-catenin, which can disrupt the Wnt signaling pathway, a pathway implicated in ciliogenesis and thus might affect CCDC103 function indirectly. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can disrupt the mTOR signaling pathway, subsequently affecting ciliary length and function, potentially affecting CCDC103's role in ciliary structure. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Binds to the barbed ends of actin filaments, preventing polymerization and thus can affect cytoskeleton organization, which is crucial for ciliogenesis, potentially influencing CCDC103's activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
A cyclin-dependent kinase inhibitor that can halt cell cycle progression, which is necessary for ciliogenesis, and might thereby affect CCDC103 indirectly. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts Golgi apparatus function and can interfere with intracellular trafficking, which is essential for ciliogenesis, potentially affecting CCDC103. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Alters cellular membrane trafficking and can inhibit ciliogenesis, which may indirectly affect CCDC103 function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase and increases cAMP levels, which can promote ciliary beat frequency and length, hence potentially affecting CCDC103 indirectly. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
High concentrations of zinc can disrupt multiple cellular processes, including ciliary function, and might thereby have an indirect effect on CCDC103. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules and can affect ciliary structure and function, which may influence CCDC103 indirectly due to its role in ciliogenesis. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Binds to tubulin, inhibiting microtubule polymerization, and can affect ciliary structure, potentially influencing CCDC103 indirectly. | ||||||