CCDC103 Inhibitors

CCDC103 inhibitors can work by disrupting cellular functions such as the actin cytoskeleton dynamics, microtubule polymerization, intracellular trafficking, cell cycle progression, and signaling pathways like Wnt, mTOR, and ROCK. For instance, chemicals that interfere with the GSK-3β enzyme, such as Lithium Chloride, can destabilize the Wnt signaling pathway, which is known to play a pivotal role in ciliogenesis, potentially leading to altered ciliary function and indirectly affecting CCDC103.

Similarly, compounds like Rapamycin, which inhibit mTOR, can result in shorter or dysfunctional cilia, implicating an indirect effect on CCDC103's role within the cilia. Other compounds, like Cytochalasin D and Y-27632, target the cytoskeleton, which is the structural framework for cilia assembly, thus potentially affecting the incorporation or function of CCDC103. The overall effect of these inhibitors is to disrupt processes critical for the proper formation and maintenance of cilia, thereby affecting the functional context in which CCDC103 operates.