CC2D2B Activators
CC2D2B Activators encompass a collection of chemical entities that facilitate the enhancement of CC2D2B's functional activity through distinct signaling mechanisms. Forskolin and Isoproterenol, by increasing intracellular cAMP, indirectly elevate the activity of CC2D2B by stimulating PKA, which may phosphorylate proteins involved in CC2D2B-dependent processes. Similarly, Rolipram preserves cAMP levels by inhibiting PDE4, thereby potentially augmenting PKA's influence on CC2D2B activity. The calcium ionophores Ionomycin and A23187 significantly increase intracellular calcium levels, which could activate calcium-dependent protein kinases that modulate CC2D2B's functionality. Epigallocatechin gallate (EGCG), through its kinase inhibition, could enhance CC2D2B's role by decreasing negative regulatory phosphorylation, while the PI3K inhibitor LY294002and the MEK1/2 inhibitor U0126 may indirectly influence CC2D2B's activity through alterations in downstream signaling pathways.
Dibutyryl-cAMP (db-cAMP) directly raises cAMP levels within cells, potentially leading to an enhancement of CC2D2B through PKA-mediated pathways. Sildenafil, by preventing cGMP breakdown, may also impact signaling cascades that positively affect CC2D2B's function. Okadaic acid, a potent inhibitor of protein phosphatases, could indirectly lead to the activation of CC2D2B by maintaining the phosphorylation state of key proteins involved in its regulation. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which may then phosphorylate substrates that modulate CC2D2B's activity, either directly or indirectly. These compounds, through their targeted actions on enzymes and second messengers, collectively amplify CC2D2B's role by modulating the phosphorylation status and signaling milieu within the cell, thereby facilitating the functional enhancement of CC2D2B without necessitating a direct interaction with the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an adenylate cyclase activator, leading to increased levels of cyclic AMP (cAMP) within the cell. Elevated cAMP could enhance CC2D2B activity by activating PKA, which might phosphorylate specific targets related to CC2D2B's function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which breaks down cAMP. By inhibiting PDE4, Rolipram maintains high levels of cAMP, potentially augmenting PKA activity and influencing CC2D2B activity through related phosphorylation events. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. By augmenting calcium signaling, it may activate pathways that interact with CC2D2B, such as calcium-dependent protein kinases that could modify CC2D2B's activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a potent antioxidant that also acts as a kinase inhibitor. By modulating kinase activity, EGCG could enhance CC2D2B activity by reducing negative regulatory phosphorylation events and thus promoting its function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels by stimulating adenylyl cyclase. This elevation in cAMP could indirectly enhance CC2D2B activity through cAMP-dependent pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that by blocking PI3K signaling can lead to alterations in downstream pathways that may intersect with CC2D2B function, potentially leading to its enhanced activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are part of the MAPK pathway. By inhibiting MEK, U0126 may shift cellular signaling balance in a way that could favor CC2D2B's activation or functional enhancement. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore like Ionomycin, and it significantly increases intracellular calcium, potentially enhancing CC2D2B activity through calcium-dependent signaling pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable analogue of cAMP. It directly raises intracellular cAMP levels, potentially enhancing CC2D2B activity through activation of cAMP-dependent protein kinases like PKA. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By preventing the dephosphorylation of proteins, it could indirectly lead to the enhanced activity of CC2D2B if it is regulated by phosphorylation. | ||||||