Cardiotrophin-2 Inhibitors
Cardiotrophin-2 inhibitors are a class of compounds that specifically target and inhibit the activity of cardiotrophin-2 (CT-2), a member of the interleukin-6 (IL-6) family of cytokines. Cardiotrophin-2 is involved in various cellular signaling pathways, particularly those that regulate cell growth, survival, and differentiation. It exerts its effects by binding to specific receptors on the cell surface, initiating intracellular signaling cascades such as the JAK/STAT and MAPK pathways. By inhibiting cardiotrophin-2, these compounds prevent the activation of these pathways, which can alter the cellular responses to external stimuli, particularly those related to growth and survival signals.
Inhibitors of cardiotrophin-2 typically work by blocking the interaction between CT-2 and its receptors or by interfering with downstream signaling components, disrupting the normal signal transduction process. These inhibitors are valuable in research focused on understanding how cardiotrophin-2 influences cellular behavior, particularly in relation to cell growth and differentiation. Researchers utilize cardiotrophin-2 inhibitors to investigate the role of this cytokine in various cellular processes, including the regulation of gene expression, cell proliferation, and apoptosis. The inhibition of CT-2 allows for a deeper understanding of how cytokine signaling pathways contribute to the regulation of physiological functions, particularly in tissues where cardiotrophin-2 is highly expressed. By modulating CT-2 activity, scientists can explore the intricate balance of signaling networks that control cell fate and behavior.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could downregulate Cardiotrophin-2 by inhibiting histone deacetylase, which may lead to a condensed chromatin state and reduced transcriptional activity of the Cardiotrophin-2 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound might decrease Cardiotrophin-2 expression by inducing DNA demethylation, potentially disrupting transcription factor binding or promoter accessibility for the Cardiotrophin-2 gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin could indirectly suppress Cardiotrophin-2 expression by inhibiting the mTOR pathway, resulting in decreased protein synthesis capacity, including that of Cardiotrophin-2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 may reduce Cardiotrophin-2 levels by interfering with the MAPK/ERK signaling cascade, possibly leading to decreased transcriptional activation of the Cardiotrophin-2 gene. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 could lead to a reduction in Cardiotrophin-2 levels by inhibiting PI3K, which might disrupt downstream signaling necessary for the expression of Cardiotrophin-2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 might reduce Cardiotrophin-2 expression by inhibiting p38 MAP kinase activity, which could impede signaling required for the upregulation of the Cardiotrophin-2 gene under stress conditions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could downregulate Cardiotrophin-2 by inhibiting NF-κB, a transcription factor that, if involved in Cardiotrophin-2 gene regulation, would lead to decreased expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might decrease Cardiotrophin-2 expression by interfering with specific survival pathways, such as SIRT1 activation, which could indirectly lower Cardiotrophin-2 gene activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 could downregulate Cardiotrophin-2 by inhibiting JNK signaling, which might be necessary for the activation of transcription factors that promote Cardiotrophin-2 gene expression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 may inhibit Cardiotrophin-2 expression by selectively blocking MEK1/2, leading to reduced ERK pathway activity and consequent downregulation of the Cardiotrophin-2 gene transcription. | ||||||