Calpain Substrates

Santa Cruz Biotechnology now offers a broad range of Calpain Substrates for use in various applications. Calpain substrates are essential tools in the study of calpains, a family of calcium-dependent cysteine proteases involved in a wide range of cellular processes, including cytoskeletal remodeling, signal transduction, and cell motility. These substrates are typically specific proteins or peptides that are recognized and cleaved by calpain enzymes, allowing researchers to monitor and quantify calpain activity in various biological systems. The study of calpain substrates is crucial for understanding how calpains selectively target proteins for limited proteolysis, a process that can alter the function, localization, or stability of target proteins. By using calpain substrates, scientists can investigate the specific roles of these proteases in cellular processes such as apoptosis, cell migration, and synaptic function, as well as their involvement in cellular responses to stress and injury. Furthermore, calpain substrates are widely used in the development of assays to measure calpain activity, providing insights into the regulation of these enzymes under different physiological and pathological conditions. These substrates are also instrumental in high-throughput screening assays designed to identify novel modulators of calpain activity, thereby expanding our understanding of the regulatory mechanisms governing calpain function. The availability of a broad range of calpain substrates enables researchers to explore the diverse roles of calpains in various biological contexts, contributing to a deeper understanding of their impact on cellular homeostasis and function. View detailed information on our available Calpain Substrates by clicking on the product name.