Calpain 3 Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene interferes with calcium release from the sarcoplasmic reticulum by antagonizing ryanodine receptors. By reducing intracellular calcium concentration, dantrolene can indirectly inhibit Calpain 3, which requires calcium for its enzymatic activity, leading to reduced proteolysis associated with this protease. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator that upon hydrolysis by intracellular esterases binds calcium ions, thereby decreasing cytosolic calcium levels. As a result, it indirectly inhibits Calpain 3 activity by limiting the calcium availability necessary for its activation. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole, commonly known for its use as a proton pump inhibitor, can also raise the pH of intracellular compartments and influence calcium sequestration. This alteration in calcium handling can indirectly reduce Calpain 3 activation, as the protease is dependent on calcium ions. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that impedes the influx of calcium through the L-type calcium channels. By reducing calcium availability in the muscle cells, verapamil can decrease the activation of Calpain 3, thereby indirectly inhibiting its proteolytic activity. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $53.00 $94.00 $135.00 | 7 | |
Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels, modulating calcium influx and potentially affecting downstream signaling pathways that can regulate protease activity, including Calpain 3, by limiting available calcium required for its function. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB acts as an inhibitor of IP3 receptors and store-operated calcium entry, affecting the calcium homeostasis within cells. By modulating calcium signaling, 2-APB can indirectly lead to the inhibition of Calpain 3 activity due to decreased levels of calcium which is crucial for the protease's activity. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry and store-operated calcium channels, disrupting the calcium homeostasis in cells. The decrease in intracellular calcium levels can, therefore, indirectly inhibit Calpain 3 by reducing the calcium-dependent proteolytic processing that Calpain 3 mediates. | ||||||
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil is a calcium channel blocker that decreases intracellular calcium levels by inhibiting both voltage-gated calcium channels and the release of calcium from intracellular stores. This reduction in calcium levels can indirectly inhibit the activity of calcium-dependent enzymes such as Calpain 3. | ||||||
Flunarizine | 52468-60-7 | sc-337841 | 5 g | $560.00 | ||
Flunarizine is a selective calcium entry blocker with calmodulin-binding properties and histamine H1 blocking activity. This compound's action reduces the cytosolic calcium levels, indirectly inhibiting Calpain 3 activity by diminishing the calcium ion concentration necessary for the proteases activity. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
TMB-8 (Trifluoperazine) is known to inhibit intracellular calcium release, impacting the function of enzymes that are dependent on calcium ions, such as Calpain 3. By reducing the availability of calcium, TMB-8 can indirectly inhibit the enzymatic activity of Calpain 3. | ||||||