Caldesmon Inhibitors
Caldesmon inhibitors are a class of chemical compounds that play a crucial role in regulating cellular processes by targeting the protein caldesmon. Caldesmon is a key regulator of smooth muscle contraction, a process vital for various physiological functions in the human body, such as the constriction and relaxation of blood vessels and the movement of food through the digestive system. These inhibitors act by interfering with the normal functioning of caldesmon, thereby influencing the contractile activity of smooth muscle cells. The primary mechanism of action of caldesmon inhibitors lies in their ability to bind to caldesmon, preventing it from binding to actin filaments within muscle cells. Actin filaments are a fundamental component of the cytoskeleton, and their interaction with caldesmon is essential for the regulation of muscle contraction. When caldesmon inhibitors bind to caldesmon, they disrupt this interaction, leading to a decrease in the ability of muscle cells to contract. This inhibition of smooth muscle contraction can have various physiological effects, such as relaxing blood vessels, which can be beneficial in certain contexts.
In summary, caldesmon inhibitors represent a class of chemical compounds that exert their effects by interfering with the interaction between caldesmon and actin filaments in smooth muscle cells. This disruption in the normal regulatory mechanisms of muscle contraction can lead to changes in cellular physiology, with potential implications in various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
Calpeptin inhibits caldesmon by binding to calpain, preventing its activation and subsequent cleavage of caldesmon, thus maintaining the inhibitory state of caldesmon on actin-myosin interactions. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is a selective inhibitor of myosin light chain kinase (MLCK), which indirectly affects caldesmon by reducing the phosphorylation of myosin light chains and promoting caldesmon's inhibitory activity. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 inhibits caldesmon by interfering with calmodulin (CaM), which is required for caldesmon's activation. W-7 disrupts the CaM-caldesmon interaction, keeping caldesmon in an inhibitory state. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is another MLCK inhibitor that prevents the phosphorylation of myosin light chains, indirectly promoting the inhibitory effect of caldesmon on actin-myosin interactions. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases, including PP1 and PP2A, which are involved in dephosphorylating caldesmon. Inhibition leads to increased phosphorylation and activation of caldesmon. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments, preventing their depolymerization and enhancing the inhibitory effect of caldesmon on actin-myosin interactions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), which regulates actin-myosin contraction. Inhibition of ROCK indirectly promotes caldesmon's inhibitory function. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin selectively inhibits myosin II ATPase activity, preventing actin-myosin interaction and reducing the need for caldesmon's inhibition. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML-141 is a small-molecule inhibitor of the G-protein-coupled receptor GPR54, which indirectly influences caldesmon through its downstream signaling pathways. | ||||||