Date published: 2025-9-10

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CALCOCO2_Calcoco2 Activators

CALCOCO2/Calcoco2 Activators are typically small molecules or peptides that have been identified through various screening methods for their ability to bind to and enhance the function of the CALCOCO2 protein. The interaction between these activators and CALCOCO2 may lead to alterations in the protein's conformation, promoting its interaction with other components of the autophagy pathway, such as LC3 (microtubule-associated proteins 1A/1B light chain 3) and GABARAP (GABA(A) receptor-associated protein) family members, which are involved in autophagosome formation.

Additionally, such activators could influence the post-translational modifications of CALCOCO2, which are known to regulate its activity and stability. By modulating the activity of CALCOCO2, these activators can serve as valuable tools in the study of autophagy-related processes and contribute to the understanding of how cargo recognition and binding efficiency affect the overall dynamics of autophagy. Research involving CALCOCO2/Calcoco2 Activators is typically focused on delineating the molecular basis of autophagy regulation and the role of autophagy receptors in cellular quality control mechanisms.

Items 11 to 12 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$65.00
$210.00
26
(2)

2-DG is a glucose analog that inhibits glycolysis and can stimulate AMPK, promoting autophagy. CALCOCO2's role in selective autophagy could be enhanced due to increased autophagic flux.

Piperlongumine

20069-09-4sc-364128
10 mg
$107.00
(1)

Piperlongumine has been shown to induce autophagy via ROS generation and JNK pathway activation. This can lead to the activation of CALCOCO2 through increased autophagic cargo degradation.