Calbindin D28K Activators
Common Calbindin D28K Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, 1α,25-Dihydroxyvitamin D3 CAS 32222-06-3, Kainic acid monohydrate CAS 58002-62-3, Lithium CAS 7439-93-2 and Caffeine CAS 58-08-2.
Calbindin D28K, a member of the EF-hand family of calcium-binding proteins, plays a pivotal role in calcium signaling and homeostasis within cells. Located primarily in the brain, especially in the cerebellum, hippocampus, and cortex, as well as in the kidneys and other tissues, Calbindin D28K acts as a buffer, reducing intracellular calcium concentrations and protecting cells from calcium-induced toxicity. By binding to calcium ions, it moderates the fluctuations of intracellular calcium, ensuring that the levels remain within a physiological range. Its expression and activity have been associated with neuroprotection, especially in situations where neurons might be exposed to excessive calcium levels, which can trigger cell death.
Activators of Calbindin D28K are compounds designed to elevate or enhance the protein's expression or its calcium-binding efficiency. These activators might act by stabilizing the protein, increasing its half-life, or promoting its transcription and translation, thereby leading to increased protein levels within the cell. Another mechanism of action might involve facilitating the interaction of Calbindin D28K with calcium ions, thereby increasing its binding efficiency. The ultimate goal of such activators would be to amplify the natural protective function of Calbindin D28K, especially in situations where cells, particularly neurons, are at risk of calcium-induced damage. This could have broad implications for cellular health, especially in contexts where calcium homeostasis is disrupted. As calcium signaling is a ubiquitous process, influencing a myriad of cellular activities from enzyme function to gene expression, the impact of modulating Calbindin D28K activity is vast, spanning across various biological systems and processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Known to modulate neuronal differentiation, retinoic acid might influence the expression of Calbindin D28K in specific neuronal populations. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
This active form of vitamin D can upregulate Calbindin D28K expression, particularly in the intestine, as part of calcium homeostasis. | ||||||
Kainic acid monohydrate | 58002-62-3 | sc-269283 | 10 mg | $275.00 | ||
An excitatory amino acid that induces neuronal activity, potentially leading to increased Calbindin D28K expression as a protective response. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Known to influence various neuronal pathways, lithium might modulate Calbindin D28K expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
By modulating calcium signaling in neurons, caffeine might influence Calbindin D28K expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
With its neuroprotective properties, curcumin might upregulate Calbindin D28K expression as a defense mechanism against neurotoxicity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, with its neuroprotective effects, might influence the expression of Calbindin D28K in neural tissues. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As a neurosteroid, estradiol can modulate the expression of various neuronal proteins, potentially including Calbindin D28K. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Its antioxidant properties might induce Calbindin D28K expression as a protective mechanism against oxidative stress in neurons. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing cAMP levels, forskolin can modulate various cellular pathways, potentially influencing Calbindin D28K expression. | ||||||