cadherin-29 Inhibitors
Cadherin-29 inhibitors are a range of chemical compounds that impede the adhesive interactions facilitated by Cadherin-29. The inhibition process is mediated through several biochemical pathways that either directly target Cadherin-29 or its associated signaling mechanisms. For example, EGTA, as a calcium chelator, debilitates Cadherin-29's calcium-dependent adhesion by sequestering calcium ions, crucial for its function. Similarly, Y-27632, a Rho Kinase inhibitor, disrupts the actin cytoskeleton dynamics, weakening the structural support needed for Cadherin-29's cell-cell adhesion. Marimastat, an MMP inhibitor, prevents proteolytic cleavage of Cadherin-29's extracellular domain, essential for adhesion, while the Src Family Kinase Inhibitor PP 2 directly hinders phosphorylation events that enhance Cadherin-29's adhesion capability.
In conjunction with these, inhibitors like FH535 and NSC95397 target the cadherin-catenin complex, a nexus essential for Cadherin-29's cell adhesion, by disrupting β-catenin and p120-catenin, respectively. The Calmodulin Antagonist W-7 indirectly diminishes Cadherin-29's function by obstructing calmodulin-dependent signaling pathways, whereas Wortmannin and SB-216763 inhibit PI3K and GSK-3, pivotal in Cadherin-29 trafficking and phosphorylation of associated proteins. Trichostatin A, an HDAC inhibitor, can reduce the expression of molecules vital for Cadherin-29's adhesion pathway, leading to diminished function. Lastly, Gö 6983 and PD 0325901, as inhibitors of PKC and MEK, respectively, destabilize Cadherin-29-mediated adhesion by thwarting phosphorylation processes within its signaling domain, resulting in a comprehensive down-regulation of Cadherin-29's adhesion capacity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
EGTA, by binding calcium ions, diminishes the calcium-dependent cell adhesion mediated by Cadherin-29 as it requires calcium ions for its adhesive function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits Rho-associated protein kinase, which disrupts the actin cytoskeleton dynamics. This leads to a reduction in the cell adhesion properties of Cadherin-29 by altering the linkage between the cytoskeleton and cadherin. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat inhibits matrix metalloproteinases (MMPs) that can cleave the extracellular domain of Cadherin-29, reducing its ability to mediate cell-cell adhesion. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP 2 inhibits Src family kinases that phosphorylate Cadherin-29, which normally enhances its adhesive function. Inhibition of Src kinases leads to a reduction in Cadherin-29-mediated cell adhesion. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 inhibits β-catenin, a protein that interacts with the cytoplasmic domain of Cadherin-29. Inhibition of β-catenin disrupts the cadherin-catenin complex, diminishing Cadherin-29 mediated cell adhesion. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 antagonizes calmodulin, which is important for various signaling pathways that support Cadherin-29's adhesive function. Inhibiting calmodulin can diminish Cadherin-29-mediated cell adhesion. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits PI3K, which is involved in cellular signaling that can affect the trafficking and turnover of Cadherin-29. Inhibition of PI3K leads to decreased cell surface expression of Cadherin-29. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB-216763 inhibits GSK-3, which can phosphorylate proteins that interact with Cadherin-29, affecting its adhesive function. Inhibition of GSK-3 thus diminishes Cadherin-29's cell adhesion capabilities. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases which can regulate gene expression of molecules involved in Cadherin-29's adhesion pathway. Inhibition leads to reduced expression and function of Cadherin-29. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Gö 6983 inhibits protein kinase C, which is involved in phosphorylation events that can stabilize Cadherin-29 function. Inhibition of PKC destabilizes Cadherin-29-mediated adhesion. | ||||||