CaBP8 Activators
CaBP8 activators refer to a class of chemical compounds that specifically interact with and modulate the activity of a protein known as Calcium Binding Protein 8 (CaBP8). This protein belongs to a larger family of calcium-binding proteins that play crucial roles in the regulation of calcium signaling pathways within cells. Calcium ions are pivotal in various cellular processes, acting as a universal signaling molecule. The precise modulation of calcium ion concentrations in different cellular compartments is essential for maintaining cellular function and homeostasis. CaBP8, in particular, has distinct calcium-binding properties and affinities, which allow it to sense and regulate intracellular calcium levels.
The chemical compounds classified as CaBP8 activators are characterized by their ability to bind to CaBP8 and influence its activity. The binding of these activators to CaBP8 can lead to a conformational change in the protein, which may alter its interaction with other proteins and molecules within the cell. This modulation can affect the protein's role in calcium signaling cascades, potentially impacting the dynamics of calcium-dependent processes. The exact mechanism of action of CaBP8 activators can vary depending on the structure and affinity of the compound in question. These activators are typically the subject of biochemical studies aimed at understanding the intricate mechanisms of calcium homeostasis and signaling. By elucidating the molecular interactions between CaBP8 and its activators, researchers can gain insights into the fundamental processes that govern cellular function and the intricate web of signaling pathways that are essential to life.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcimycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can bind to CaBP8, enhancing its activation and ability to bind to target proteins involved in calcium signaling pathways, thus potentially increasing its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased cAMP levels in cells. Elevated cAMP can activate PKA, which may phosphorylate proteins that interact with or regulate CaBP8, thereby enhancing its activity in calcium-dependent cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates that modulate calcium signaling. PKC-mediated phosphorylation events can lead to the functional enhancement of CaBP8 by altering its interaction with other proteins in calcium signaling pathways. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K8644 is an L-type calcium channel agonist that increases calcium influx. The influx of calcium can directly bind to CaBP8, potentially enhancing its conformation and interaction with target proteins, thus promoting its role in calcium-mediated signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels. This rise in intracellular calcium can enhance the activation of CaBP8 by increasing its calcium binding and subsequent involvement in calcium-dependent signaling. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine modulates the release of calcium from sarcoplasmic/endoplasmic reticulum by binding to ryanodine receptors. This modulation can lead to increased intracellular calcium, which may enhance CaBP8 activity by promoting its calcium-binding function. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine is an L-type calcium channel blocker that modulates calcium influx. By altering calcium dynamics, it can indirectly enhance CaBP8 activity by affecting the localisation and availability of calcium for binding to CaBP8 in specific cellular compartments. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is another L-type calcium channel blocker that can alter calcium homeostasis in cells. This alteration may enhance CaBP8's activity by modulating the intracellular calcium levels available for CaBP8 binding, affecting its role in calcium signaling. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can release intracellular calcium stores by modulating ryanodine receptors. This release of calcium may indirectly enhance the activity of CaBP8 by increasing the availability of calcium ions that can bind to and activate CaBP8. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
DOG is a synthetic diacylglycerol analog that can activate PKC. Activation of PKC could lead to phosphorylation events that indirectly enhance CaBP8 activity by modifying the calcium signaling environment in which CaBP8 operates. | ||||||