C9orf119 Inhibitors

The "SWI5 Homologous Recombination Repair Protein" (SWI5 HRRP) is a theoretical protein associated with the cellular mechanism of homologous recombination repair (HRR), a critical process for maintaining genomic stability. Homologous recombination is a high-fidelity DNA repair pathway that is particularly active during the S and G2 phases of the cell cycle when sister chromatids are available as templates for repairing DNA double-strand breaks (DSBs).SWI5 HRRP is likely named after the SWI5 gene, which in yeast encodes a protein that plays a role in the regulation of the cell cycle and is involved in the repair of DSBs through homologous recombination. Drawing parallels from the yeast SWI5, the SWI5 HRRP in higher eukaryotes could be implicated in the recruitment of repair machinery to the sites of DSBs, ensuring that the HRR pathway is efficiently initiated.

The involvement of SWI5 HRRP in HRR suggests it may interact with key components of the repair process, such as the RAD51 recombinase, which catalyzes the strand invasion and exchange steps of HRR. SWI5 HRRP could function to enhance the formation of the RAD51 nucleoprotein filament, which is essential for searching for and pairing with the homologous DNA sequence on the sister chromatid.Furthermore, SWI5 HRRP might be involved in the resolution of Holliday junctions, the crossover structures formed during recombination, thereby facilitating the accurate completion of the repair process. It might also have a role in the regulation of the cell cycle checkpoints to ensure that cells do not proceed through mitosis with unresolved DNA damage, which could lead to chromosomal aberrations and genomic instability.