C8orf38 Inhibitors
NADH:ubiquinone oxidoreductase complex assembly factor 6, also known by the gene name NDUFAF6, is a chaperone protein implicated in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex, known as complex I. This complex is the largest and the first enzyme of the mitochondrial respiratory chain, which plays a central role in cellular energy production through oxidative phosphorylation.
Complex I consists of over 40 different subunits and has the fundamental task of transferring electrons from NADH to ubiquinone, coupled with the translocation of protons across the mitochondrial inner membrane. This process is pivotal for the generation of a proton gradient, which drives the synthesis of ATP by ATP synthase. Proper assembly and function of complex I are crucial for efficient energy production and cellular metabolism.The role of NDUFAF6 is to ensure the correct assembly and integration of the numerous subunits into a functional complex I. It acts as an assembly factor, a type of protein that assists in the folding and assembly of other protein complexes, but is not a part of the final functional complex. Mutations in the NDUFAF6 gene can disrupt the assembly of complex I and lead to mitochondrial diseases, typically presenting as mitochondrial encephalomyopathies.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is known to impact mitochondrial function and can indirectly affect complex I activity, potentially influencing processes associated with NDUFAF6. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. While not specific to NDUFAF6, it can provide insights into complex I function and assembly. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $285.00 | 24 | |
Like Rotenone, Piericidin A is a complex I inhibitor and may indirectly affect NDUFAF6 function by impacting overall complex I activity. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO is often used as a solvent in biological studies but can also influence mitochondrial function, potentially affecting NDUFAF6-related processes. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits complex III of the mitochondrial electron transport chain, which can indirectly affect complex I and processes related to NDUFAF6. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits ATP synthase (complex V). Alterations in ATP synthase activity can indirectly influence complex I assembly and NDUFAF6 function. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
MitoQ is a mitochondrial-targeted antioxidant. It can influence mitochondrial dynamics and function, potentially impacting NDUFAF6-associated processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences mitochondrial biogenesis and function, which could indirectly affect NDUFAF6 function in complex I assembly and activity. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits complex IV of the electron transport chain, which can have indirect effects on complex I assembly and NDUFAF6 function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, Rapamycin can influence mitochondrial dynamics and biogenesis, potentially impacting NDUFAF6 function in complex I assembly. | ||||||