C6orf167 Inhibitors

C6orf167 inhibitors pertain to a class of chemical compounds designed to interact with the protein encoded by the human gene C6orf167, also known as MICAL3 (molecule interacting with CasL protein 3). The name C6orf167 arises from its initial characterization as an open reading frame (ORF) on chromosome 6. The proteins in the MICAL family are known to be multi-domain flavoenzymes, which means they have the capacity to catalyze oxidation-reduction (redox) reactions using flavin adenine dinucleotide (FAD) as a cofactor. The precise biological function of C6orf167 is complex and multifaceted, involving the regulation of cytoskeletal dynamics. This includes its influence on actin filament disassembly and interactions with other proteins that are crucial for the maintenance of various cellular functions.

Inhibitors targeting C6orf167 are chemical agents that have been developed to specifically bind to this protein and modulate its activity. The design of such compounds typically stems from an understanding of the enzyme's structure and the key active sites that are essential for its enzymatic function. By binding to the MICAL3 protein, these inhibitors can affect the protein's ability to interact with its substrates or with other proteins within the cell. The development of inhibitors often involves the use of high-throughput screening techniques to identify potential molecules that demonstrate a high affinity for the target protein.