C5orf46 Activators
C5orf46 is a protein whose activity is influenced by intricate cellular signaling pathways, and its functional activity can be modulated through various biochemical mechanisms. Compounds that elevate intracellular levels of cyclic AMP may serve as indirect activators of C5orf46 by stimulating protein kinase A, which could phosphorylate and activate the protein if it is part of the cAMP-dependent signaling cascade. Similarly, the inhibition of phosphodiesterases raises both cAMP and cGMP levels, potentially enhancing the protein's activity via the same cyclic nucleotide pathways. Additionally, the modulation of intracellular calcium through the use of calcium ionophores can trigger a cascade of calcium-dependent signaling events, potentially increasing theactivity of C5orf46 if it is linked to such pathways. Ionophores that specifically increase calcium concentration within cells could activate calmodulin-dependent kinases or other calcium-sensitive enzymes, possibly leading to the activation of C5orf46.
Furthermore, the protein's activity may be regulated by kinase signaling pathways, with certain compounds known to activate protein kinase C, potentially resulting in an upregulation of C5orf46 if it is downstream of PKC. Other signaling molecules that inhibit various kinases, such as those within the NF-κB, PI3K/Akt, and MAPK pathways, might lead to compensatory responses within the cell that enhance C5orf46 activity. For example, the inhibition of NF-κB could activate alternative pathways that upregulate C5orf46, while the inhibition of PI3K or MEK might also trigger feedback mechanisms that increase the protein's activity. Additionally, the inhibition of protein phosphatases could lead to a general increase in phosphorylation levels within the cell, potentially resulting in the enhanced activity of C5orf46 if its function is controlled by its phosphorylation state. Lastly, compounds that influence ion channel functions and intracellular signaling environments may also play a role in modulating the activity of C5orf46.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, which increases intracellular cAMP and cGMP by preventing their degradation. The rise in cAMP levels could enhance C5orf46 activity if C5orf46 is modulated by such cyclic nucleotide signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that increases intracellular calcium levels. If C5orf46 activity is calcium-dependent, ionomycin would indirectly increase C5orf46 activity by augmenting intracellular calcium, which can activate calcium-sensitive signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A diester of phorbol that acts as a potent activator of protein kinase C (PKC). If C5orf46 is part of or regulated by PKC-mediated signaling, PMA could indirectly upregulate C5orf46 activity through PKC pathway activation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
An inhibitor of NF-κB activation by blocking the phosphorylation of IκBα. If C5orf46 activity is positively regulated through an NF-κB dependent pathway, inhibition of NF-κB may result in compensatory mechanisms that upregulate C5orf46 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of PI3K, leading to downregulation of the Akt signaling pathway. If C5orf46 operates downstream of PI3K/Akt, inhibition of Akt could result in feedback mechanisms that enhance C5orf46 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAPK. If C5orf46 is part of a signaling cascade modulated by p38 MAPK, inhibition of p38 MAPK could lead to compensatory activation of C5orf46 through alternative signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK, which is upstream of ERK in the MAPK pathway. Inhibition of MEK could trigger a compensatory response that leads to increased C5orf46 activity, assuming C5orf46 is linked to MAPK signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore which increases intracellular calcium levels and could enhance C5orf46 activity by activating calcium-dependent pathways that C5orf46 may be part of. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels within the cell. If C5orf46 function is modulated by phosphorylation status, okadaic acid could indirectly increase its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
An inhibitor of protein phosphatases, which could cause an increase in C5orf46 activity by promoting its phosphorylation if C5orf46 is regulated by dephosphorylation events. | ||||||