C5orf24 Inhibitors
C5orf24 inhibitors employ diverse mechanisms to attenuate the functional activity of this protein by specifically targeting pathways and processes that it influences. Some inhibitors interact with the mTOR signaling axis, a critical conduit for cellular growth and proliferation signals; by suppressing mTOR activity, these agents indirectly throttle the activity of C5orf24, presuming it participates in this signaling cascade. Additionally, inhibitors that obstruct phosphoinositide 3-kinases (PI3K) curtail the activation of downstream elements like AKT, resulting in a dampened signal transduction that could impinge on C5orf24's functional sphere. Other compounds assail the MAPK/ERK pathway by inhibiting MEK, leading to the attenuation of C5orf24's involvement in cell signaling. Moreover, p38 MAPK inhibitors may disrupt stress response pathways that, if linked with C5orf24, could result in its diminished activity.
C5orf24 inhibitors also encompass agents that affect gene expression indirectly by altering the epigenetic landscape, such as histone deacetylase inhibitors, which by remodeling chromatin structure may downregulate pathways regulating C5orf24. JNK inhibitors compromise cell processes including apoptosis, which, if C5orf24 is a participant, could lead to a reduction in its activity. ROCK inhibitors that perturb cell motility and structural integrity could likewise result in a decrement of C5orf24 activity should it be implicated in these processes. Aurora kinase inhibitors, by impinging on cell cycle progression, and tyrosine kinase inhibitors, affecting growth factor signaling, might also curtail the functional spectrum of C5orf24. Additionally, proteasome inhibitors could lead to an accumulation of regulatory proteins that control cell cycle and apoptosis, potentially suppressing C5orf24 activity if it is intertwined with these cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of PI3K, LY 294002 impedes the PI3K/AKT pathway. Since C5orf24 is downstream of AKT, inhibition of PI3K reduces AKT phosphorylation and activity, leading to reduced activity of C5orf24. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This compound is a selective inhibitor of MEK, which blocks the MAPK/ERK pathway. C5orf24, being regulated by ERK signaling, is indirectly inhibited when the MEK-induced ERK activation is blocked. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, Rapamycin suppresses the mTOR signaling pathway. C5orf24, which functions downstream of mTORC1, experiences reduced activity due to the cessation of mTORC1 signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A specific inhibitor of p38 MAPK, SB 203580 impedes the p38 MAPK signaling pathway. C5orf24 is indirectly inhibited as it is a downstream effector of the p38 MAPK pathway, and its activity is diminished when p38 MAPK is inhibited. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
As an inhibitor of PI3K, Wortmannin disrupts the PI3K/AKT pathway. The activity of C5orf24 is indirectly diminished since it operates downstream of this pathway and relies on its signals for proper functioning. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of JNK, SP600125 reduces JNK signaling, which is crucial for the activation of transcription factors that regulate C5orf24. Therefore, inhibition of JNK signaling leads to decreased C5orf24 activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Specifically targets the AKT pathway and inhibits its activity. C5orf24, which acts downstream of AKT, has reduced functional activity when AKT is inhibited by Triciribine. | ||||||
LY3214996 | 1951483-29-6 | sc-507299 | 5 mg | $260.00 | ||
An ERK1/2 inhibitor that halts the MAPK/ERK pathway. As C5orf24 is a downstream target of this pathway, its activity is indirectly decreased due to the inhibition of ERK1/2 by LY3214996. | ||||||
INK 128 | 1224844-38-5 | sc-364511 sc-364511A | 5 mg 50 mg | $315.00 $1799.00 | ||
A selective mTOR kinase inhibitor that prevents mTORC1 and mTORC2 signaling. With mTOR signaling being essential for C5orf24 activity, INK 128 decreases C5orf24 activity by inhibiting mTORC1 and mTORC2. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
A flavonoid that has been shown to inhibit protein kinase C (PKC). Since PKC is involved in pathways regulating C5orf24, the inhibition of PKC by Apigenin leads to a decrease in C5orf24 functional activity. | ||||||