C2orf37 Activators
C2orf37 Activators are a diverse set of chemical compounds that indirectly enhance the functional activity of C2orf37 through various intracellular signaling pathways and molecular mechanisms. Compounds such as Forskolin and IBMX operate by elevating intracellular cAMP levels, leading to increased activity of PKA, which could phosphorylate C2orf37 or proteins that regulate its activity, thereby enhancing its function. Similarly, PMA, through the activation of PKC, and Anisomycin, by activating stress-activated protein kinase pathways like JNK, could lead to phosphorylation events that indirectly increase C2orf37 activity. Polyamine-based modulation by Spermine could influence intracellular signaling pathways by affecting the ionic environment, thus potentially enhancing C2orf37 function, while Nicotinamide, by contributing to NAD+ biosynthesis,could affect sirtuin activity and modulate the acetylation status of proteins involved in C2orf37's functional regulation. Retinoic acid indirectly influences C2orf37 by altering the gene expression patterns of interacting or regulatory proteins, and Zinc pyrithione may modulate the activity of metalloproteins that interact with C2orf37, affecting its functionality through changes in metal ion homeostasis.
In addition to these mechanisms, other activators such as Curcumin and Resveratrol exert their effects by inhibiting pathways like NF-κB or activating sirtuins, respectively, which may result in the reduction of negative regulation or post-translational modification of proteins that are critical for C2orf37 activity. Curcumin could thus lift inhibition on regulatory proteins, and Resveratrol might enhance C2orf37 function through sirtuin-mediated deacetylation. Similarly, Epigallocatechin gallate (EGCG) could disrupt kinase activities, shifting the balance of cellular phosphorylation and potentially leading to enhanced C2orf37 activity. Lastly, Sodium butyrate, as an HDAC inhibitor, could create a chromatin environment that favors the transcription of genes encoding proteins that affect C2orf37 function, offering an additional layer of indirect activation through epigenetic modulation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP, indirectly leading to increased PKA activity. This can enhance the phosphorylation status of proteins, including C2orf37, thereby potentially increasing its functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which may lead to the phosphorylation of proteins that interact with C2orf37, potentially enhancing its activity through altered protein-protein interactions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) inhibits certain types of kinases and, by altering the cellular phosphorylation balance, could indirectly enhance the activity of C2orf37 by modulating the function of proteins that regulate C2orf37 activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is an inhibitor of protein synthesis that can activate stress-activated protein kinase pathways such as JNK, which may lead to phosphorylation events affecting C2orf37 activity directly or through intermediary proteins. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can modulate ion channel function and indirectly influence intracellular signaling pathways. This modulation may enhance the activity of C2orf37 by affecting the ionic environment and protein interactions within the cell. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is a form of vitamin B3 that acts as a precursor for NAD+, which is a cofactor in redox reactions and can affect sirtuin activity. Sirtuins can deacetylate proteins and potentially modulate C2orf37 activity through changes in protein acetylation status. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates gene expression by activating nuclear receptors. Through altering gene expression patterns, it can indirectly influence the activity of C2orf37 by affecting the expression of proteins that interact with or regulate C2orf37. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione can modulate metalloprotein function and alter signal transduction pathways. This can enhance C2orf37 activity by potentially affecting the metal ion balance in proteins that interact with or regulate the function of C2orf37. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit various signaling pathways including NF-κB, which might relieve potential inhibition on proteins that regulate C2orf37 activity, thereby indirectly enhancing C2orf37 function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuins and can modulate longevity genes. Through the activation of sirtuins, it might enhance C2orf37 activity by deacetylation of C2orf37 itself or regulatory proteins associated with C2orf37. | ||||||