C20orf54 Inhibitors

The inhibitors listed are primarily focused on targeting folate metabolism and absorption, which are processes directly related to the function of SLC46A1/C20orf54. By influencing these pathways, they may indirectly affect the functionality of this folate transporter. Methotrexate, Trimethoprim, and Pyrimethamine are dihydrofolate reductase inhibitors. They affect folate metabolism, potentially impacting the transport function of SLC46A1, as it is closely linked to the cellular folate levels and metabolism. Pemetrexed and Raltitrexed, which target folate-dependent enzymes like thymidylate synthase, can indirectly affect the demand for folate transport, possibly impacting SLC46A1 functionality.

Sulfamethoxazole, a sulfonamide antibiotic, and Sulfasalazine, used in inflammatory bowel diseases, inhibit folate synthesis, which could indirectly affect SLC46A1-mediated folate transport. Proton Pump Inhibitors like Omeprazole may alter intestinal pH, which can influence the intestinal absorption of folate, thereby potentially impacting the function of SLC46A1. Levamisole and Zidovudine impact folate metabolism and absorption. Their effects could extend to modifying the interaction between folate and SLC46A1. Phenytoin and Glucocorticoids like Prednisone are known to interfere with various aspects of cellular metabolism, including folate utilization. Their use might indirectly influence SLC46A1's transport activity.