C20orf26 Inhibitors

Cilia and flagella associated protein 61 (CFAP61) is a protein that, as its name suggests, is associated with the structure and function of cilia and flagella-hair-like organelles that protrude from the surface of many eukaryotic cells. Cilia and flagella are critical for a variety of cellular processes, including motility, fluid movement, sensing the cellular environment, and cell signaling.

CFAP61 is believed to be involved in the assembly or stability of the axonemal dynein arms, which are motor protein complexes that drive the bending and movement of cilia and flagella. The precise molecular function of CFAP61 is still under investigation, but it is postulated to be essential for the correct formation and maintenance of these organelles. Mutations in the gene encoding CFAP61 have been linked to ciliopathies, a group of disorders characterized by defective cilia formation or function. These diseases can manifest in a variety of ways, as cilia are ubiquitous across different tissue types and play multifaceted roles in organismal development and function. For instance, defective ciliary movement due to disruptions in CFAP61 may result in respiratory issues, infertility, or problems with the sensory systems, highlighting its importance across multiple physiological systems.