C20orf111 Inhibitors
Oxidative Stress Responsive Serine Rich 1 (OSR1) is a protein that plays a critical role in the cellular response to oxidative stress. Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the cell's ability to detoxify them or to repair the resulting damage. ROS are chemically reactive molecules containing oxygen, such as peroxides and superoxide, which can lead to cellular damage if not regulated.OSR1 contains serine-rich regions, which are often indicative of proteins that undergo extensive post-translational modifications such as phosphorylation. Phosphorylation of serine residues can significantly alter a protein's function, typically modulating its activity, localization, or interactions with other proteins. The presence of serine-rich domains in OSR1 suggests it may be regulated in this manner, especially under conditions of oxidative stress.
The function of OSR1 is associated with its ability to sense increased levels of ROS and to participate in signaling pathways that help protect the cell. This may include activating transcription factors that induce the expression of antioxidant enzymes, which work to neutralize ROS, or enhancing the cell's capacity for repair.OSR1's exact mechanisms of action are not fully understood, but it likely interacts with other proteins involved in stress response and cellular homeostasis. It may also be involved in other biological processes independent of its role in oxidative stress response, as serine-rich proteins often have multifunctional capacities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone indirectly inhibits OSR1 by antagonizing aldosterone, which can modulate the activity of OSR1 in kidney cells, affecting ion transport and osmoregulation. | ||||||
Eplerenone | 107724-20-9 | sc-203943 sc-203943A | 10 mg 50 mg | $108.00 $612.00 | 4 | |
Eplerenone, like Spironolactone, indirectly inhibits OSR1 through aldosterone antagonism, thereby influencing OSR1-mediated pathways in osmoregulation and ion transport. | ||||||
Torsemide | 56211-40-6 | sc-213059 | 10 mg | $260.00 | ||
Torsemide inhibits OSR1 indirectly by acting as a loop diuretic, altering kidney function and potentially impacting OSR1-related pathways involved in ion transport and osmotic balance. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
Furosemide is a loop diuretic that can indirectly affect OSR1 activity by altering ion transport in the kidneys, which is a process regulated by OSR1. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Hydrochlorothiazide, a thiazide diuretic, indirectly inhibits OSR1 by affecting sodium and chloride transport in the distal convoluted tubule, potentially impacting OSR1 activity. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Amiloride indirectly affects OSR1 activity by acting as a potassium-sparing diuretic, influencing sodium and potassium balance, which are regulated by OSR1-mediated pathways. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $53.00 | ||
Triamterene is a potassium-sparing diuretic that can indirectly inhibit OSR1 by influencing ion transport and osmoregulation in the kidneys, where OSR1 is active. | ||||||
Chlorthalidone | 77-36-1 | sc-207427 | 25 mg | $243.00 | 1 | |
Chlorthalidone, similar to Hydrochlorothiazide, is a thiazide-like diuretic that indirectly affects OSR1 by altering ion transport in the kidney, potentially impacting OSR1-regulated pathways. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $107.00 $224.00 | 9 | |
Bumetanide is a loop diuretic that indirectly inhibits OSR1 by affecting ion transport in the loop of Henle, which is a process where OSR1 is involved. | ||||||
Indapamide | 26807-65-8 | sc-204777 sc-204777A | 250 mg 1 g | $45.00 $63.00 | ||
Indapamide, a thiazide-like diuretic, indirectly affects OSR1 activity by influencing ion transport in the kidneys, impacting OSR1-mediated osmoregulation. | ||||||