C1orf158_1700012P22Rik Inhibitors
C1orf158_1700012P22Rik inhibitors are chemical entities designed to attenuate the activity of the C1orf158_1700012P22Rik protein through various intracellular signaling mechanisms. These inhibitors are not generic in their action; rather, they exert their effects by strategically targeting pathways and processes that C1orf158_1700012P22Rik is known to be involved in. For example, when kinase activity is inhibited, phosphorylation-dependent activation of C1orf158_1700012P22Rik can be reduced, assuming that it is phosphorylation-regulated. Inhibitors that interfere with PI3K/Akt signaling or the MAPK/ERK pathway, both of which are pivotal in controlling a broad range of cellular functions, could lead to an indirect decrease in C1orf158_1700012P22Rik activity if it is part of these cascades. This is particularly significant considering the multitude of proteins that these pathways influence, encompassing various aspects of cell growth, differentiation, and survival, where the functional activity of C1orf158_1700012P22Rik might be crucial.
In addition to the kinase pathway modulation, the activity of C1orf158_1700012P22Rik can also be diminished by altering the levels of key intracellular ions and molecules that serve as secondary messengers. For instance, calcium chelators disrupt calcium-dependent signaling mechanisms, potentially leading to a reduction in the activity of proteins like C1orf158_1700012P22Rik that may rely on calcium-mediated processes. Furthermore, the inhibition of other signaling proteins such as mTOR, JNK, or G-protein-coupled receptors could lead to decreased C1orf158_1700012P22Rik activity, provided there is a functional relationship. These inhibitors collectively contribute to a comprehensive approach to diminish the activity of C1orf158_1700012P22Rik, showcasing the intricate interplay between chemical inhibitors and the multifaceted signaling networks within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent protein kinase inhibitor, which by inhibiting protein kinases, may decrease the phosphorylation of C1orf158_1700012P22Rik, leading to reduced activity of this protein if its function is regulated by phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphoinositide 3-kinases (PI3K) inhibitor that can diminish the PI3K/Akt signaling pathway. If C1orf158_1700012P22Rik is downstream of this pathway, its activity could be indirectly diminished due to reduced downstream signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor which, by inhibiting mTORC1, might lead to a decrease in the functional activity of C1orf158_1700012P22Rik if it is involved in growth factor-related signaling pathways that converge on mTOR. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An MEK inhibitor which reduces the MAPK/ERK pathway activity. If C1orf158_1700012P22Rik activity is reliant on the ERK signaling, its functionality could be indirectly diminished by this compound. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAPK which can lead to decreased activation of the MAPK pathway. Should C1orf158_1700012P22Rik function be influenced by stress-activated protein kinase pathways, this inhibitor could diminish its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK) which could decrease the functional activity of C1orf158_1700012P22Rik if it is modulated by the JNK signaling pathway. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
A potent and selective inhibitor of Gs-alpha GTPase that might inhibit signaling pathways involving G protein-coupled receptors, potentially diminishing the functional activity of C1orf158_1700012P22Rik if GPCR signaling is involved. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A calcium chelator that can diminish intracellular calcium levels, thereby potentially inhibiting calcium-dependent signaling pathways that might regulate the activity of C1orf158_1700012P22Rik. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
An inhibitor of calmodulin-dependent protein kinases. If C1orf158_1700012P22Rik activity is calcium/calmodulin-dependent, W-7 could result in decreased activity of the protein. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A SERCA pump inhibitor which causes an increase in cytosolic calcium, potentially leading to diminished activity of C1orf158_1700012P22Rik if it is negatively regulated by high intracellular calcium levels. | ||||||