C18orf37 Inhibitors

The INO80 complex subunit C, also known as INO80C, is a component of the INO80 chromatin remodeling complex, which plays a vital role in DNA-based processes within the nucleus of eukaryotic cells. INO80C is a highly conserved protein across various species, indicating its significance in cellular functions.The INO80 complex, where INO80C is a subunit, is involved in the regulation of transcription, DNA repair, and replication. It works by utilizing the energy from ATP hydrolysis to modify the positioning and composition of nucleosomes, which are the structural units of chromatin. This chromatin remodeling is crucial for allowing access of transcription factors and other DNA-binding proteins to genomic DNA.

INO80C's specific role within the INO80 complex is not as well characterized as the catalytic subunit INO80 itself, but it is believed to contribute to the structural integrity and functional regulation of the complex. It may also be involved in recruiting the INO80 complex to particular regions of chromatin, where it can then carry out its remodeling functions.Mutations or dysregulation of INO80C and other components of the INO80 complex have been implicated in cancer and other diseases because of their role in maintaining genomic stability. When cells are unable to properly modify chromatin structure, it can lead to errors in gene expression and DNA repair, contributing to the development of disease.